CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HRH3; HRH4; HRH1;
Hydrolase	ACHE;
Protein Phosphatase	CDC25B;
Enzyme_unclassified	BLM; HSD17B1; GFER; ALOX15;
Protein Kinase	CSNK2A1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Transcription Factor	NFKB1;
Unclassified	LMNA; FABP4; THPO;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220

Showing 1 to 10 of 22 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.531E-07	2.564E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.683E-06	1.551E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008610; lipid biosynthetic process	1.781E-06	1.551E-03	ACHE, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.238E-06	1.805E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	3.278E-06	2.302E-03	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	7.420E-06	3.798E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.852E-05	7.688E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.852E-05	7.688E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.591E-05	9.958E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.905E-11	8.292E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4

Showing 1 to 10 of 18 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.866E-08	3.579E-06	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.169E-08	3.579E-06	PLA2G1B, CYP1A2, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.548E-06	7.175E-05	PLA2G1B, ALOX15, CYP2C19, PTGS2, PTGS1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.505E-05	2.490E-04	MAOA, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.038E-04	1.155E-03	CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.311E-04	1.193E-03	MAOA, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.632E-04	1.238E-03	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.377E-04	1.194E-03	CYP1A2, XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.894E-04	1.951E-03	GSK3B, CDK6, SYK, PRKCA, TP53, NFKB1, TLR2
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	1.947E-04	1.417E-03	GSK3B, CSNK2A1, PRKCA, TP53, PPARD

Showing 1 to 10 of 41 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	HRH4;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; NFKB1; ACHE; HRH1; CDC25B;
C00-D49: Neoplasms	Allergic conjunctivitis	C91.0, H10, H10.45, T78.4	HRH1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HRH1; HRH3;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Plantago depressa

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities