CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA14;
Enzyme_unclassified	ALOX12; GFER; HSD17B10; NOX4; POLB;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Unclassified	LMNA; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.121E-08	6.797E-05	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, PIM1
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	6.112E-07	7.394E-04	ALOX12, CDK1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, TSHR
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.041E-06	1.030E-03	AXL, CA2, CDK1, CYP1B1, FABP4, KDR, MMP9
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.874E-06	1.956E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	3.714E-06	2.186E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	1.316E-05	5.507E-03	ALOX12, IGF1R, KDR, MET, MMP9, NOX4
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	2.103E-05	7.762E-03	ALOX12, AXL, CA2, FABP4, FLT3, MET, NOX4, NPSR1, POLB
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	1.346E-06	1.224E-03	ALOX12, AURKB, AXL, CA14, CA2, CDK1, CYP1B1, FLT3, GFER, HSD17B10, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NOX4, PIM1, POLB

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.856E-04	2.529E-03	CA2, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.437E-04	2.237E-03	KDR, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	6.736E-04	7.343E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.979E-07	3.247E-05	FLT3, MMP1, MMP2, MET, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.725E-06	1.354E-04	MMP2, KDR, MMP9, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.066E-06	1.126E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.571E-05	4.280E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.354E-05	5.132E-04	PIM1, CYP1B1, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.257E-05	7.734E-04	FLT3, PIM1, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.342E-04	2.837E-03	MMP2, PIM1, NFKB1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MMP9; MMP2;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Centipeda minima

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities