CMAUP Plant Collective Molecular Activities

Plant Name: Glehnia littoralis

Taxonomic Information:

Plant ID: NPO8874
Plant Latin Name: Glehnia littoralis
Taxonomy Genus: Glehnia
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 48119
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Analgesic; Antibacterial; Antipyretic; Diaphoretic; Expectorant

Geographical Distribution:

South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Hydrolase	ACHE;
Transient receptor potential channel	TRPV1;
Protein Kinase	AXL; FLT3; CDK1; PIM1; MET; KDR; IGF1R; AURKB;
Enzyme_unclassified	ADK; ALOX12; HSD17B10; ALOX15; NOX4; POLB;
Lyase	CA12; CA9; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Unclassified	HTT; LMNA; FABP3; FABP5; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1A2; CYP2A6; CYP1B1; CYP2A13; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transient receptor potential channel	TRPV1	Vanilloid receptor	Q8NER1	CHEMBL4794
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.181E-12	2.017E-08	CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.205E-12	2.552E-08	CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2C9, CYP2D6, NOX4
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.099E-11	1.528E-07	ALOX12, ALOX15, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.500E-10	4.469E-07	CYP1A2, CYP2C19, CYP2C9, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	4.325E-10	4.709E-07	CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, NOX4
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.421E-09	2.483E-06	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, FFAR4, HTT, IGF1R, KDR, LMNA, MMP9, NFKB1, PIM1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.868E-09	3.312E-06	CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.144E-08	7.115E-06	CYP1A2, CYP2A6, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.285E-08	7.581E-06	CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.138E-08	1.667E-05	CA12, CA4, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	5.453E-08	2.761E-05	CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.009E-07	8.748E-05	CYP1A2, CYP1B1, CYP2A13, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.176E-07	9.113E-05	CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	3.835E-07	1.369E-04	CYP2A13, CYP2A6, CYP2D6
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.835E-07	1.369E-04	ADORA1, ADORA2A, ADORA3
MF	GO:0005488; binding	GO:0005504; fatty acid binding	3.955E-07	1.389E-04	FABP3, FABP4, FABP5, FFAR4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	4.148E-07	1.434E-04	ADORA1, ADORA2A, CA7, HTT, KDR, NPSR1, TRPV1
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	9.175E-07	2.895E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.308E-06	3.888E-04	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.392E-06	6.763E-04	CYP1A2, CYP2C9, CYP2D6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.974E-06	7.995E-04	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.071E-06	1.175E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.071E-06	1.175E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	5.071E-06	1.175E-03	CYP2A13, CYP2A6
MF	Unclassified;	GO:0004872; receptor activity	5.186E-06	1.189E-03	ADORA1, ADORA2A, ADORA3, AXL, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, PPARA, TRPV1, TSHR
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	6.184E-06	1.374E-03	ADORA1, ADORA2A, FFAR4, NFKB1, PPARA
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	6.413E-06	1.411E-03	ALOX12, CA12, CA7, FABP3, FABP4, FFAR1, HTT, MET, NOX4, NPSR1, TRPV1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	8.387E-06	1.756E-03	ALOX15, AXL, CDK1, CYP1A2, CYP1B1, FABP4, KDR, MMP9
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	9.574E-06	1.913E-03	ADORA1, ADORA2A, ADORA3, AXL, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, TRPV1, TSHR
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.519E-05	2.689E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.519E-05	2.689E-03	ALOX12, ALOX15
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.519E-05	2.689E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.933E-05	3.238E-03	CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.449E-05	3.950E-03	FABP3, FABP4, FABP5
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.034E-05	4.685E-03	CYP1A2, CYP2C9
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	3.132E-05	4.757E-03	ADORA2A, CA9, CDK1, CYP1A2, CYP1B1, FLT3, NFKB1, NOX4, TRPV1
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	3.189E-05	4.757E-03	ADORA1, CYP1A2, CYP1B1, FABP3, FABP4, FABP5
MF	GO:0005488; binding	GO:0036094; small molecule binding	4.973E-05	6.854E-03	ADK, ADORA1, AURKB, AXL, CDK1, FABP3, FABP4, FABP5, FFAR4, FLT3, IGF1R, KDR, MET, NOX4, PIM1, TRPV1
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	5.049E-05	6.872E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	5.236E-05	7.039E-03	ACHE, ADORA3, ALOX15, CDK1, PPARA
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	6.283E-05	8.143E-03	AXL, FLT3, IGF1R, KDR, MET

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.213E-08	1.492E-06	CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.458E-08	1.512E-06	CYP2C9, CYP2A6, CYP2A13, CYP1A2, CYP1B1, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.126E-07	9.528E-06	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.126E-07	9.528E-06	FABP3, FABP4, FABP5, MMP1, PPARA
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.748E-08	1.947E-06	CA12, CA4, CA7, CA9
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.593E-06	8.071E-05	CYP2C9, CYP2D6, ALOX15, ALOX12, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.648E-07	9.528E-06	CYP2C9, CYP1A2, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.343E-05	3.201E-04	FLT3, MMP1, MMP2, MET, MMP9, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.036E-05	1.592E-04	CYP2C9, ALOX15, ALOX12, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	8.073E-05	7.638E-04	MMP2, KDR, MMP9, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.348E-05	7.532E-04	ADORA2A, ADORA1, PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	4.564E-05	5.267E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.432E-04	2.483E-03	ADORA2A, ADORA3, ADORA1, TRPV1, TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.675E-04	2.057E-03	FLT3, PIM1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.538E-04	2.057E-03	FABP4, ADORA1, TSHR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	9.989E-05	8.776E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.719E-04	3.055E-03	PIM1, CYP1B1, MMP9, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.175E-03	7.224E-03	ADORA2A, KDR, MET, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.424E-03	8.343E-03	MMP2, PIM1, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.945E-04	2.696E-03	CYP2C9, CYP2A6, CYP1A2
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.537E-03	8.593E-03	KDR, MET, NFKB1, IGF1R
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.710E-05	5.267E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A; TRPV1;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	TRPV1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MMP9; MMP2; CA9;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	TRPV1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; ADORA3; MMP9; MMP2; CA9;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CA9;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; ADORA2A; ADK; TRPV1;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; FFAR1;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6; ADORA3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
NA: NA	Esophagus sensitivity	NA	TRPV1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A; TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Acute or chronic pain	R52, G89	TRPV1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	TRPV1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pathological pain	R52, G89	TRPV1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases