CMAUP Plant Collective Molecular Activities

Plant Name: Rubus occidentalis

Taxonomic Information:

Plant ID: NPO8865
Plant Latin Name: Rubus occidentalis
Taxonomy Genus: Rubus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 75079
Plant-of-the-World-Online: 223350-2

Used in Medicines:

Country/Region:

United States

Traditional Medicine System:

Medicinal Functions:

Astringent; Cathartic; Ophthalmic; Pectoral; Salve; TB; VD

Geographical Distribution:

Canada; United States; Georgia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	PLA2G1B; AKR1B10; GFER; HSD17B10; ALDH1A1; POLB;
Protein Kinase	MAPK1;
Lyase	CA12; CA9; CA7;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Cysteine protease	CASP1; CASP7;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.066E-06	6.324E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.647E-07	6.324E-03	CA12, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	4.066E-06	6.324E-03	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.066E-06	6.324E-03	GPBAR1, NR1H4
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	8.126E-06	8.524E-03	NMUR2, PLA2G1B
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	8.126E-06	8.524E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	8.126E-06	8.524E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.126E-06	8.524E-03	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.838E-05	1.667E-02	AKR1B10, ALDH1A1
MF	GO:0005488; binding	GO:0051379; epinephrine binding	3.781E-05	1.915E-02	ADRA2A, ADRA2C

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.939E-07	1.073E-04	CA12, CA7, CA9
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	8.499E-05	5.099E-03	CASP7, CASP1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	8.956E-04	1.822E-02	MAPK1, ADRA2C, ADRA2A
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	1.619E-02	PLA2G1B, CYP1A2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	9.112E-04	1.822E-02	CASP7, MAPK1, HSD17B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.396E-04	1.619E-02	AKR1B10, GAA
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.261E-03	3.015E-02	AKR1B10, PLA2G1B, GAA, CYP1A2, ALDH1A1, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.810E-03	2.914E-02	CASP7, CASP1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.943E-03	2.914E-02	CASP1, MAPK1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	3.022E-02	CYP1A2, ALDH1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Breast cancer	C50	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CDC25B; CA9;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases