CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; AOX1;
Protein Kinase	EGFR;
Lyase	CA2; CA7; CA12;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242

Showing 1 to 10 of 14 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.626E-08	1.579E-04	CYP1A1, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.000E-07	7.919E-04	CYP1A1, CYP1B1, CYP2C9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	1.991E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.861E-06	2.251E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.134E-06	2.445E-03	CA12, CA2, CA7
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.369E-06	3.190E-03	BLM, CYP1A1, CYP1B1, EGFR, ESR1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.944E-06	3.431E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	4.254E-06	3.431E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	6.070E-06	4.558E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.283E-05	7.982E-03	BLM, CA2, CYP1A1, CYP1B1, EGFR

Showing 1 to 10 of 18 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.657E-06	8.767E-05	CYP1A1, AOX1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.846E-07	1.218E-05	CA12, CA2, CA7
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.163E-05	2.558E-04	CYP2C9, CYP1A1, AOX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.650E-05	2.722E-04	CYP2C9, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	7.464E-03	CYP2C9, AOX1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.355E-04	6.068E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	4.116E-05	4.528E-04	ESR1, EGFR, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.468E-04	5.156E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.131E-03	7.464E-03	ESR1, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.340E-05	3.089E-04	CYP2C9, CYP1A1, CYP1B1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Melanoma	C43	EGFR;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	EGFR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Crotalaria orixensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities