CMAUP Plant Collective Molecular Activities

Plant Name: Kniphofia tuckii

Taxonomic Information:

Plant ID: NPO8827
Plant Latin Name: Kniphofia tuckii
Taxonomy Genus: Kniphofia
Taxonomy Family: Asphodelaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Enzyme_unclassified	HSD17B10;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A13; CYP2D6; CYP1A2; CYP2A6; CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.711E-14	1.863E-10	CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.795E-14	2.029E-10	CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.033E-13	4.500E-10	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.663E-13	1.139E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.161E-13	1.733E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.794E-12	3.550E-09	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.321E-11	4.254E-08	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.214E-11	5.098E-08	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	2.023E-10	2.203E-07	CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	7.325E-10	6.815E-07	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.512E-10	6.815E-07	CYP1A2, CYP2A13, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	6.403E-09	4.497E-06	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.193E-08	1.291E-05	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	3.538E-07	1.712E-04	CYP2A13, CYP2A6
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	3.515E-07	1.712E-04	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.061E-06	4.621E-04	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.121E-16	4.619E-12	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.408E-05	1.714E-02	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.227E-12	9.225E-11	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.741E-12	9.225E-11	CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.572E-12	1.262E-10	CYP2C9, CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.750E-09	4.637E-08	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.931E-08	1.045E-06	CYP2C9, CYP2A6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.456E-07	7.872E-06	CYP2C9, CYP2D6, MAPK1, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.731E-05	4.944E-04	CYP2C9, CYP2A6, CYP1A2, CYP2C19, CYP3A4, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.211E-04	1.427E-03	MAPK1, MAPT, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.117E-04	5.403E-03	CYP2C9, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3.366E-04	3.568E-03	CYP2A6, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.354E-04	5.160E-03	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.297E-06	4.992E-05	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases