CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Lyase	CA2; CA1; CA7; CA12; CA9; CA14;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 10 of 10 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.043E-14	2.224E-10	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.214E-12	1.835E-08	CA1, CA12, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	1.432E-03	CA2, CA7
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.083E-05	1.310E-02	CA2, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.876E-05	2.150E-02	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.914E-07	1.799E-03	CA1, CA12, CA2, CA7, CA9, NR1H4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.614E-06	5.622E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.456E-17	3.170E-13	CA1, CA12, CA14, CA2, CA7, CA9

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.921E-17	3.505E-16	CA12, CA1, CA2, CA7, CA9, CA14
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.785E-02	8.142E-02	LMNA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.490E-04	3.294E-03	CA2, NR1H4
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.342E-02	4.026E-02	CA2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.144E-02	4.026E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	3.640E-02	6.265E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.699E-02	6.265E-02	CA2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3.640E-02	6.265E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	4.074E-02	6.265E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	4.411E-02	6.265E-02	LMNA

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aconitum fauriei

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities