CMAUP Plant Collective Molecular Activities

Plant Name: Xylopia emarginata

Taxonomic Information:

Plant ID: NPO8738
Plant Latin Name: Xylopia emarginata
Taxonomy Genus: Xylopia
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Potassium channels	KCNA3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Potassium channels	KCNA3	Voltage-gated potassium channel subunit Kv1.3	P22001	CHEMBL4633

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.905E-14	1.383E-10	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	5.238E-13	2.281E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.044E-12	5.564E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.850E-11	6.206E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.332E-11	1.056E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.789E-10	3.196E-07	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.826E-10	6.343E-07	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.403E-09	6.062E-06	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.145E-08	4.309E-05	CYP1A1, CYP1A2, CYP1B1
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	7.770E-08	5.834E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.752E-07	3.869E-04	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.752E-07	3.869E-04	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	3.149E-06	1.693E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0009056; catabolic process	4.723E-06	2.285E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	7.417E-06	3.106E-03	CYP1A2, CYP2C9
BP	GO:0009987; cellular process	GO:0071280; cellular response to copper ion	8.764E-06	3.601E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.527E-05	6.046E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.362E-16	5.143E-12	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.896E-16	8.597E-12	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
CC	GO:0016020; membrane	GO:0031090; organelle membrane	8.975E-04	2.246E-01	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	1.992E-02	1.000E+00	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.136E-11	2.777E-10	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.214E-09	1.439E-08	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.669E-09	2.456E-08	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.580E-07	6.707E-07	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.110E-07	1.107E-06	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.556E-08	3.106E-07	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.136E-06	2.110E-06	CYP2C9, CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.362E-06	2.213E-06	CYP2C9, CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.711E-05	2.472E-05	CYP2C9, CYP1A2, CYP1A1, CYP2C19, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.966E-04	2.556E-04	CYP2C9, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.408E-04	7.574E-04	CYP2C9, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.749E-03	1.895E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	KCNA3;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic arthritis	L40.5, M07	KCNA3;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases