CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPL; ALDH1A1;
Protein Kinase	MAPK1;
Lyase	CA7; CA12; CA9;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Transcription Factor	TP53; NFKB1;
Unclassified	MAPT; LMNA; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.453E-06	2.877E-03	ALPL, CA9, CNR1, CYP1A2, MAPK1, NFKB1, TP53
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	1.990E-06	3.610E-03	CNR1, CNR2, MAPK1, NFKB1, PPARA, TP53, TSHR
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	2.764E-06	4.300E-03	CA7, CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	3.143E-06	4.521E-03	ALPL, CNR1, CNR2, CYP1A2, NFKB1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.971E-06	5.008E-03	CA12, CA7, CA9
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	4.370E-06	5.008E-03	CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0035094; response to nicotine	5.912E-06	6.437E-03	CNR1, MAPK1, NFKB1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.333E-06	7.604E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.559E-07	1.115E-03	CA12, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	2.186E-06	3.662E-03	CNR1, CNR2

Showing 1 to 10 of 10 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.443E-07	4.476E-05	CA12, CA7, CA9
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.371E-03	7.233E-03	CYP1A2, ALDH1A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.045E-05	5.593E-04	MAPK1, PPARA, NFKB1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	5.391E-05	7.998E-04	MAPK1, MAPT, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.347E-04	1.592E-03	MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.548E-03	7.233E-03	CNR2, CNR1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.797E-03	9.975E-03	MAPK1, TP53, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.100E-06	2.210E-04	LMNA, MAPK1, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.581E-05	5.593E-04	FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.347E-04	1.592E-03	MAPK1, TP53, NFKB1

Showing 1 to 10 of 37 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MAPK1; TP53; CA9;

Showing 1 to 10 of 51 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Zanthoxylum schinifolium

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities