CMAUP Plant Collective Molecular Activities

Plant Name: Acorus tatarinowii

Taxonomic Information:

Plant ID: NPO8666
Plant Latin Name: Acorus tatarinowii
Taxonomy Genus: Acorus
Taxonomy Family: Acoraceae

Plant External Links:

NCBI TaxonomyDB: 123564
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; PTAFR; FFAR4; FFAR1;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Enzyme_unclassified	BLM; PKM; HSD17B10; ALOX15;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
GABA-A receptor	GABRR1;
Protein Kinase	MAPK1;
Transcription Factor	TP53;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	LMNA; FABP3; FABP4; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	PTAFR	Platelet activating factor receptor	P25105	CHEMBL250
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	3.372E-11	1.836E-07	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.896E-10	8.255E-07	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	2.161E-08	2.774E-05	GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	3.115E-08	3.230E-05	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	1.809E-07	1.203E-04	GRIK3, GRM1, GRM8
MF	Unclassified;	GO:0004872; receptor activity	2.361E-07	1.512E-04	ADORA3, FFAR1, FFAR4, GABRR1, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, PTAFR
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	3.036E-07	1.836E-04	GABRR1, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
CC	GO:0044464; cell part	GO:0043204; perikaryon	4.079E-07	2.338E-04	GRIK3, GRIK5, MAPK1, SMN1, SMN2
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	1.116E-06	5.651E-04	GRIK1, GRIK3, GRM1, GRM8
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	4.318E-06	1.881E-03	GABRR1, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005488; binding	GO:0005504; fatty acid binding	6.198E-06	2.595E-03	FABP3, FABP4, FFAR4
CC	GO:0044464; cell part	GO:0042995; cell projection	6.497E-06	2.669E-03	GRIA2, GRIA4, GRIK3, GRIK5, GRM1, MAPK1, MAPT, PKM, SMN1, SMN2
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	1.044E-05	3.987E-03	GRIA2, GRIA4
CC	GO:0044425; membrane part	GO:0008328; ionotropic glutamate receptor complex	3.163E-05	9.699E-03	GRIA2, GRIA4, GRIK5
BP	GO:0023052; signaling	GO:0023051; regulation of signaling	3.315E-05	9.756E-03	ALOX15, BLM, FFAR1, FFAR4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, KMT2A, LMNA, MAPK1, MAPT, TP53

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.327E-14	1.725E-12	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, MAPK1, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.649E-13	6.272E-11	GRIA2, GABRR1, GRIK5, ADORA3, PTAFR, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.797E-07	7.788E-06	GRIA2, GABRR1, MAPK1, GRM1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	1.866E-05	6.066E-04	GRIA2, GABRR1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	6.354E-05	1.642E-03	GRIA2, MAPK1, GRM1
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	8.453E-05	1.642E-03	GRIA2, MAPK1, GRM1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	8.841E-05	1.642E-03	PKM, MAPK1, TP53
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	2.494E-04	4.052E-03	GRIA2, MAPK1, GRIA4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.757E-04	9.118E-03	LMNA, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.952E-04	7.152E-03	ADORA3, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	8.417E-04	9.118E-03	GRM8, MAPK1, GRM1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	6.457E-04	8.394E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTAFR;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTAFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	PTAFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3; MAPK1; TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PTAFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Thrombocytopenia	D69.6, P61.0	PTAFR;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	PTAFR;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
H00-H59: Diseases of the eye and adnexa	Ocular allergy	H00-H59	PTAFR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
J00-J99: Diseases of the respiratory system	Asthma	J45	PTAFR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PTAFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; PTAFR; GRIK1; PKM;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1; MAPT;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Solid tumours	C00-D48	PTAFR; MAPK1; PKM; TP53;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRIK1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
H00-H59: Diseases of the eye and adnexa	Conjunctivitis	H10	PTAFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PTAFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PTAFR;
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	PTAFR;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	PTAFR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	PTAFR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases