CMAUP Plant Collective Molecular Activities

Plant Name: Triticum aestivum

Taxonomic Information:

Plant ID: NPO8589
Plant Latin Name: Triticum aestivum
Taxonomy Genus: Triticum
Taxonomy Family: Poaceae

Plant External Links:

NCBI TaxonomyDB: 4565
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Israel; Australia; Italy; South Africa; India; Lebanon; Madagascar; Russia; United States; Zimbabwe; China; Swaziland; Angola; Argentina; South Korea; Spain

Traditional Medicine System:

Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM

Medicinal Functions:

Antibilious; Antihydrotic; Antipruritic; Antipyretic; Antivinous; Sedative; Skin; Stomachic

Geographical Distribution:

Turkey; Israel; Australia; Angola; South Africa; Lebanon; India; Madagascar; United States; Zimbabwe; China; South Korea; Swaziland; Italy; Argentina; Russia; Spain

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HCAR2;
Hydrolase	GAA;
Transient receptor potential channel	TRPA1;
Enzyme_unclassified	P4HB; HKDC1; AKR1B1; USP2;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.862E-05	1.443E-01	AKR1B1, MAPT, P4HB, TRPA1, USP2
BP	GO:0008152; metabolic process	GO:0044262; cellular carbohydrate metabolic process	2.400E-05	1.443E-01	AKR1B1, GAA, HKDC1
BP	GO:0008152; metabolic process	GO:0019318; hexose metabolic process	2.651E-05	1.443E-01	AKR1B1, GAA, HKDC1
BP	GO:0009987; cellular process	GO:0019725; cellular homeostasis	1.687E-04	4.509E-01	GAA, HKDC1, P4HB, TRPA1
BP	GO:0008152; metabolic process	GO:0006091; generation of precursor metabolites and energy	2.738E-04	4.509E-01	AKR1B1, GAA, HKDC1
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.274E-04	4.509E-01	AKR1B1, MAPT
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	8.282E-04	5.278E-01	GAA
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	1.242E-03	5.634E-01	GAA
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	1.656E-03	6.803E-01	GAA
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	2.069E-03	6.882E-01	TRPA1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.697E-07	3.563E-06	GAA, HKDC1, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2.133E-04	1.493E-03	GAA, HKDC1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.903E-05	7.248E-04	HKDC1, AKR1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.049E-02	4.407E-02	GAA, HKDC1, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.431E-02	4.443E-02	AKR1B1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.904E-02	4.443E-02	HKDC1
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	1.786E-02	4.443E-02	HKDC1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1.904E-02	4.443E-02	HKDC1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.649E-02	4.636E-02	HKDC1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	1.999E-03	1.049E-02	HKDC1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	TRPA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases