Plant Name: Echinocystis fabacea
Taxonomic Information:
Plant ID: NPO8562
Plant Latin Name: Echinocystis fabacea
Taxonomy Genus: Echinocystis
Taxonomy Family: Cucurbitaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | CHEK2 | Serine/threonine-protein kinase Chk2 | O96017 | CHEMBL2527 |
| Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
| Protein Kinase | CHEK1 | Serine/threonine-protein kinase Chk1 | O14757 | CHEMBL4630 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 2.460E-10 | 3.802E-06 | CHEK1, CHEK2, MAP2K1, MAPK1 |
| BP | GO:0009987; cellular process | GO:0090170; regulation of Golgi inheritance | 1.930E-07 | 1.050E-03 | MAP2K1, MAPK1 |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 2.986E-07 | 1.300E-03 | CHEK1, CHEK2, MAP2K1, MAPK1 |
| BP | GO:0032501; multicellular organismal process | GO:0060440; trachea formation | 4.823E-07 | 1.750E-03 | MAP2K1, MAPK1 |
| BP | GO:0032501; multicellular organismal process | GO:0060020; Bergmann glial cell differentiation | 9.002E-07 | 2.450E-03 | MAP2K1, MAPK1 |
| BP | GO:0009987; cellular process | GO:0006975; DNA damage induced protein phosphorylation | 9.002E-07 | 2.450E-03 | CHEK1, CHEK2 |
| BP | GO:0009987; cellular process | GO:0080135; regulation of cellular response to stress | 1.271E-06 | 2.836E-03 | CHEK1, CHEK2, MAP2K1, MAPK1 |
| BP | GO:0009987; cellular process | GO:0090399; replicative senescence | 2.121E-06 | 4.199E-03 | CHEK1, CHEK2 |
| BP | GO:0051179; localization | GO:2000641; regulation of early endosome to late endosome transport | 4.370E-06 | 5.286E-03 | MAP2K1, MAPK1 |
| MF | Unclassified; | GO:0004708; MAP kinase kinase activity | 3.374E-06 | 5.286E-03 | MAP2K1, MAPK1 |
| BP | GO:0032502; developmental process | GO:0060324; face development | 4.916E-06 | 5.634E-03 | MAP2K1, MAPK1 |
| BP | GO:0032501; multicellular organismal process | GO:0030878; thyroid gland development | 8.864E-06 | 7.720E-03 | MAP2K1, MAPK1 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 3.406E-05 | 2.054E-02 | CHEK1, CHEK2, MAP2K1, MAPK1 |
| CC | GO:0043226; organelle | GO:0005815; microtubule organizing center | 1.348E-04 | 4.586E-02 | CHEK1, MAP2K1, MAPK1 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 2.883E-04 | 7.749E-02 | MAP2K1, MAPK1 |
| CC | GO:0044422; organelle part | GO:0000781; chromosome, telomeric region | 4.303E-04 | 9.863E-02 | CHEK1, CHEK2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.216E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05020 | Prion diseases | 1.781E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 4.604E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 2.454E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| Unclassified | Unclassified | hsa04320 | Dorso-ventral axis formation | 1.051E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 3.965E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 4.771E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 6.214E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 5.469E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 5.290E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 5.651E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 6.408E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04664 | Fc epsilon RI signaling pathway | 6.804E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 6.408E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 6.408E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 6.605E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 7.421E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 7.633E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 7.847E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 7.847E-05 | 3.326E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 7.007E-05 | 3.326E-04 | CHEK2, CHEK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.168E-04 | 4.332E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 1.116E-04 | 4.332E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 1.221E-04 | 4.348E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 1.417E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 1.142E-04 | 4.332E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 1.276E-04 | 4.367E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 1.446E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 1.475E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 1.505E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.818E-04 | 4.577E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.565E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 1.658E-04 | 4.472E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 1.596E-04 | 4.439E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.786E-04 | 4.577E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.851E-04 | 4.577E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 2.125E-04 | 4.729E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.055E-04 | 4.729E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 2.233E-04 | 4.809E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04270 | Vascular smooth muscle contraction | 2.125E-04 | 4.729E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.125E-04 | 4.729E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 2.572E-04 | 5.281E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.892E-04 | 5.477E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 2.611E-04 | 5.281E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 2.690E-04 | 5.319E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 2.269E-04 | 4.809E-04 | CHEK2, CHEK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.145E-04 | 5.599E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04072 | Phospholipase D signaling pathway | 3.060E-04 | 5.558E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 2.851E-04 | 5.477E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 2.975E-04 | 5.517E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04921 | Oxytocin signaling pathway | 3.682E-04 | 6.426E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04022 | cGMP-PKG signaling pathway | 4.113E-04 | 7.039E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 4.515E-04 | 7.582E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05034 | Alcoholism | 4.723E-04 | 7.785E-04 | MAP2K1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 5.153E-04 | 8.339E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 6.069E-04 | 9.313E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 5.833E-04 | 9.271E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 6.010E-04 | 9.313E-04 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 6.189E-04 | 9.336E-04 | CHEK1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 6.555E-04 | 9.723E-04 | MAP2K1, MAPK1 |
| 09140 Cellular Processes | 09142 Cell motility | hsa04810 | Regulation of actin cytoskeleton | 6.741E-04 | 9.836E-04 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 7.581E-04 | 1.088E-03 | MAP2K1, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 9.553E-04 | 1.350E-03 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 9.777E-04 | 1.360E-03 | CHEK2, CHEK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.700E-03 | 2.293E-03 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.293E-03 | 1.770E-03 | MAP2K1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.297E-03 | 3.051E-03 | MAP2K1, MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CHEK1; CHEK2; MAPK1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CHEK1; CHEK2; MAPK1; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CHEK1; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | CHEK1; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | CHEK1; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CHEK1; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
