CMAUP Plant Collective Molecular Activities

Plant Name: Erythrina abyssinica

Taxonomic Information:

Plant ID: NPO8526
Plant Latin Name: Erythrina abyssinica
Taxonomy Genus: Erythrina
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 1237573
Plant-of-the-World-Online: 494336-1

Used in Medicines:

Country/Region:

Kenya; Tanzania; Rwanda; China

Traditional Medicine System:

TCM

Geographical Distribution:

Eritrea; Angola; Sudan; Tanzania; Zimbabwe; Malawi; Ethiopia; Rwanda; China; Mozambique; Uganda; Burundi; Kenya; Botswana; Zambia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1; PTPN2;
Enzyme_unclassified	PLA2G1B;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	9.649E-08	2.101E-03	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	7.235E-07	7.877E-03	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response	1.254E-06	9.101E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	6.989E-06	2.639E-02	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	1.662E-05	4.021E-02	PTPN1, PTPN2
MF	GO:0005488; binding	GO:0030971; receptor tyrosine kinase binding	2.472E-05	4.893E-02	PTPN1, PTPN2
CC	GO:0044464; cell part	GO:0097443; sorting endosome	9.316E-04	2.504E-01	PTPN1
MF	GO:0005488; binding	GO:0097677; STAT family protein binding	9.316E-04	2.504E-01	PTPN2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	1.242E-03	2.877E-01	PTPN2
CC	GO:0044464; cell part	GO:0005783; endoplasmic reticulum	6.925E-03	7.397E-01	PTPN1, PTPN2
CC	GO:0044464; cell part	GO:0005829; cytosol	1.571E-02	1.000E+00	PLA2G1B, PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3.746E-03	2.357E-02	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.344E-03	2.357E-02	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	6.138E-03	2.357E-02	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.272E-03	2.505E-02	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00565	Ether lipid metabolism	6.735E-03	2.357E-02	PLA2G1B
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.106E-02	2.505E-02	PTPN1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.626E-02	2.505E-02	PTPN1
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1.418E-02	2.505E-02	PLA2G1B
09150 Organismal Systems	09153 Circulatory system	hsa04270	Vascular smooth muscle contraction	1.789E-02	2.505E-02	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	1.433E-02	2.505E-02	PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases