CMAUP Plant Collective Molecular Activities

Plant Name: Euonymus tingens

Taxonomic Information:

Plant ID: NPO849
Plant Latin Name: Euonymus tingens
Taxonomy Genus: Euonymus
Taxonomy Family: Celastraceae

Plant External Links:

NCBI TaxonomyDB: 1089406
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Ayurveda

Medicinal Functions:

Ophthalmic; Purgative

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	GAA;
Enzyme_unclassified	TDP1; HSD17B3; ALDH1A1; POLB;
Lyase	CA2; CA1; CA12; CA9; CA5A; CA14; CA7; CA6;
Aspartic protease	BACE1;
Transcription Factor	TP53;
Unclassified	HTT; LMNA; NPC1; SERPINA6; RAB9A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B3	Estradiol 17-beta-dehydrogenase 3	P37058	CHEMBL4234
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	SERPINA6	Corticosteroid binding globulin	P08185	CHEMBL2421
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.838E-06	6.964E-03	CA1, CA12, CA2, CA5A, CA6, CA7, CA9, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	7.429E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.810E-21	2.136E-16	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.645E-16	1.920E-12	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.421E-14	6.188E-11	CA1, CA12, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0061370; testosterone biosynthetic process	1.476E-05	1.786E-02	CYP19A1, HSD17B3
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	2.294E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.802E-20	1.541E-18	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.190E-03	6.021E-02	HSD17B3, CYP19A1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.214E-02	1.335E-01	LMNA, TP53
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	9.478E-03	1.335E-01	NPC1, GAA
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	1.149E-02	1.335E-01	RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	7.631E-02	1.419E-01	TP53
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	3.888E-02	1.419E-01	POLB
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.519E-02	1.419E-01	ALDH1A1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.742E-02	1.419E-01	TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	7.964E-02	1.419E-01	TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases