CMAUP Plant Collective Molecular Activities

Plant Name: Picrasma quassioides

Taxonomic Information:

Plant ID: NPO8372
Plant Latin Name: Picrasma quassioides
Taxonomy Genus: Picrasma
Taxonomy Family: Simaroubaceae

Plant External Links:

NCBI TaxonomyDB: 210334
Plant-of-the-World-Online: 813963-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

TCM; Unani; Ayurveda

Medicinal Functions:

Anthelmintic; Antiviral; Bitter; Febrifuge; Hypotensive; Parasiticide; Stomachic; Tonic

Geographical Distribution:

South Africa; Nepal; India; China; Japan; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRD1; NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	BLM; HSD17B10; ALOX15; POLB;
Protein Kinase	IKBKB; MAPK1; PIM1; KIT; CSNK2A1;
Lyase	CA12; CA9;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Oxidoreductase	MAOB;
Transcription Factor	HIF1A;
Unclassified	LMNA; NPC1; RAB9A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	IKBKB	Inhibitor of nuclear factor kappa B kinase beta subunit	O14920	CHEMBL1991
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	2.594E-06	5.153E-03	ACHE, ALOX15, CSNK2A1, ESR1, GAA, HIF1A, KIT, LMNA, MAOB, MAPK1, NMUR2, PIM1, POLB, SMN1, SMN2, TSHR
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	2.603E-06	5.153E-03	ADRA2A, ADRA2C, KIT, NMUR2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	2.176E-06	5.153E-03	ESR1, ESR2
BP	GO:0009987; cellular process	GO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway	8.366E-06	9.588E-03	ADRA2A, ESR1, NMUR2, OPRD1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	6.523E-06	9.588E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0005496; steroid binding	7.990E-06	9.588E-03	CYP3A4, ESR1, ESR2, NPC1
BP	GO:0007610; behavior	GO:0007610; behavior	1.173E-05	1.092E-02	GAA, HIF1A, KIT, MAPK1, NMUR2, NPC1, OPRD1
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.303E-05	1.092E-02	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	1.303E-05	1.092E-02	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.303E-05	1.092E-02	CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005886; plasma membrane	3.421E-05	1.576E-02	ACHE, ADRA2A, ADRA2C, ALOX15, CA12, CA9, CSNK2A1, ESR1, GAA, HSD17B10, KIT, MAPK1, NMUR2, OPRD1, PIM1, RAB9A, TSHR
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.423E-04	4.004E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.680E-04	4.285E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.335E-06	1.896E-04	IKBKB, KIT, PIM1, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.987E-05	9.403E-04	CYP2C9, MAOB, ALOX15, MAPK1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.765E-06	6.933E-04	CYP2C9, ALOX15, CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4.446E-05	1.578E-03	OPRD1, NMUR2, ADRA2C, ADRA2A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	8.872E-05	2.239E-03	IKBKB, MAPK1, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	9.463E-05	2.239E-03	OPRD1, MAPK1, ADRA2C, ADRA2A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.234E-04	2.390E-03	KIT, MAPK1, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.528E-04	2.411E-03	MAPK1, ESR1, ESR2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.347E-04	2.390E-03	CYP2C9, MAOB, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.915E-04	5.054E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	6.541E-04	7.740E-03	MAPK1, ESR1, HIF1A
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.724E-04	3.868E-03	CA12, CA9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases