Plant Name: Centaurea corcubionensis
Taxonomic Information:
Plant ID: NPO8343
Plant Latin Name: Centaurea corcubionensis
Taxonomy Genus: Centaurea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
1436089
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.035E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0008152; metabolic process | GO:0046415; urate metabolic process | 1.346E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 2.484E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0009987; cellular process | GO:1902175; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 3.104E-03 | 1.000E+00 | P4HB |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 6.616E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0009987; cellular process | GO:0045454; cell redox homeostasis | 7.338E-03 | 1.000E+00 | P4HB |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.074E-02 | 1.000E+00 | P4HB |
| BP | GO:0009987; cellular process | GO:0034976; response to endoplasmic reticulum stress | 2.459E-02 | 1.000E+00 | P4HB |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 1.043E-02 | 1.000E+00 | P4HB |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 3.306E-02 | 1.000E+00 | ABCG2 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 7.247E-04 | 1.000E+00 | ABCG2 |
| MF | GO:0005488; binding | GO:0046983; protein dimerization activity | 4.252E-03 | 1.000E+00 | ABCG2, P4HB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 4.395E-03 | 1.063E-02 | ABCG2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 7.088E-03 | 1.063E-02 | ABCG2 |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 1.683E-02 | 1.683E-02 | P4HB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
