CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	RECQL; TDP1; GLO1; ALOX12; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
SLC superfamily of solute carriers	SLCO1B1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0007568; aging	2.334E-07	5.648E-04	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	7.619E-07	1.037E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.356E-06	1.641E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.293E-06	2.378E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.965E-06	2.546E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.931E-06	2.767E-03	ALOX12, AURKB, AXL, CDK1, GLO1, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0072593; reactive oxygen species metabolic process	6.007E-06	3.737E-03	ALOX12, CYP1A1, CYP1B1, NOX4
BP	GO:0008283; cell proliferation	GO:0008283; cell proliferation	7.618E-06	3.962E-03	ACHE, AURKB, CDK1, CYP1A1, FLT3, MET, PIM1
BP	GO:0009987; cellular process	GO:0007346; regulation of mitotic cell cycle	8.006E-06	3.962E-03	APEX1, AURKB, CDK1, CYP1A1, L3MBTL1, PIM1, TOP2A
MF	GO:0005488; binding	GO:0005524; ATP binding	3.007E-06	2.546E-03	AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MET, PIM1, RECQL, TOP2A

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.514E-05	1.458E-03	CYP1A1, CYP1B1, IGF1R

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Ilex lepta

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities