CMAUP Plant Collective Molecular Activities

Plant Name: Vaccaria hispanica

Taxonomic Information:

Plant ID: NPO829
Plant Latin Name: Vaccaria hispanica
Taxonomy Genus: Vaccaria
Taxonomy Family: Caryophyllaceae

Plant External Links:

NCBI TaxonomyDB: 39387
Plant-of-the-World-Online: 159710-1

Used in Medicines:

Country/Region:

Turkey; India

Traditional Medicine System:

Indian Folk

Medicinal Functions:

Anodyne; Antiphlogistic; Antipruritic; Diuretic; Emmenagogue; Febrifuge; Galactogogue; Oxytoxic; Styptic; Vulnerary

Geographical Distribution:

Brazil; Turkey; Italy; Bangladesh; France; Ethiopia; Belarus; Algeria; Japan; China; Belgium; Germany; Spain; Ukraine; Eritrea; Netherlands; Libya; Poland; Mauritius; Morocco; Hungary; Switzerland; Russia; Bulgaria; United States; Romania; Albania; Portugal; South Africa; Egypt; India; Tunisia; Austria; Greece; Kenya; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	RECQL; PLA2G1B; AHCY; CDA; HSD11B1; AKR1B10; POLB;
Lyase	CA1; CA9;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
SLC superfamily of solute carriers	SLC28A1; SLC28A3; SLCO1B3; SLCO1B1;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AHCY	Adenosylhomocysteinase	P23526	CHEMBL2664
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.849E-08	9.929E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	1.238E-06	6.703E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	3.712E-06	6.736E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	3.712E-06	6.736E-03	SLC28A1, SLC28A3
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.712E-06	6.736E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.712E-06	6.736E-03	GPBAR1, NR1H4
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	5.103E-06	8.548E-03	NR1H4, SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015711; organic anion transport	5.510E-06	8.570E-03	CA1, CA9, NR1H4, PLA2G1B, SLCO1B1, SLCO1B3
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	3.453E-05	2.593E-02	ACP1, PTPN2
MF	GO:0005488; binding	GO:0032052; bile acid binding	4.436E-05	3.116E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	7.119E-05	1.353E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.290E-05	1.353E-03	SLCO1B1, SLCO1B3, NR1H4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.555E-04	1.970E-03	CA1, CA9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.332E-03	6.015E-02	PTPN1, PTPRF
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.834E-03	6.405E-02	HSD11B1, CDA, AHCY, AKR1B10, PLA2G1B
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.292E-02	7.011E-02	PTPN2, MCL1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.011E-02	6.405E-02	PTPN1, PTPRF
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.176E-02	9.884E-02	CDC25B, MCL1
09100 Metabolism	09103 Lipid metabolism	hsa00565	Ether lipid metabolism	4.837E-02	9.884E-02	PLA2G1B
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4.942E-02	9.884E-02	CDA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDA;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; CA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases