CMAUP Plant Collective Molecular Activities

Plant Name: Asclepias vestita

Taxonomic Information:

Plant ID: NPO8263
Plant Latin Name: Asclepias vestita
Taxonomy Genus: Asclepias
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 660014
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; ALDH1A1; HSD17B2;
Hydrolase	ACHE;
Lyase	CA7; CA4; CA12;
Oxidoreductase	ALDH2;
Transcription Factor	HIF1A;
Unclassified	NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP2D6; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Oxidoreductase	ALDH2	Aldehyde dehydrogenase	P05091	CHEMBL1935
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.528E-12	7.682E-08	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.870E-08	8.144E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, HSD17B2, NPC1
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.442E-08	1.071E-04	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.532E-08	1.233E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	8.300E-08	1.506E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	8.300E-08	1.506E-04	CYP1A2, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.714E-07	2.871E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.997E-07	7.668E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.494E-06	1.414E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.235E-06	1.946E-03	CYP2C19, CYP2C9, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	2.373E-06	1.987E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.664E-06	2.148E-03	CA12, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.374E-06	2.449E-03	CYP1A2, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.923E-06	3.353E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.764E-06	3.692E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.179E-05	6.699E-03	CYP1A2, CYP2D6
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	3.992E-05	1.932E-02	CYP1A2, CYP2C19, CYP2C9, CYP2D6, HSD17B2, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.721E-07	4.267E-06	CYP2C9, CYP2D6, CYP1A2, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.233E-06	1.520E-05	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.306E-07	4.267E-06	CA12, CA4, CA7
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.450E-05	1.341E-04	CYP2C9, CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.057E-05	1.522E-04	CYP2C9, CYP2D6, CYP1A2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.406E-05	3.915E-04	CYP2C9, CYP2D6, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.917E-05	1.799E-04	CYP2C9, CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.720E-04	7.954E-04	CYP2C9, ALDH2, HSD17B2, CYP1A2, ALDH1A1, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.028E-04	1.656E-03	ALDH2, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	3.254E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.471E-04	3.134E-03	CYP1A2, HSD17B2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ALDH2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ALDH2;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	ALDH2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases