CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPL; PGD; USP2; BRCA1;
Miscellaneous ion channel	BCL2;
Protein Kinase	MAPK1;
Lyase	CA2; CA14; CA7;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53; NFKB1;
Plant homeodomain	KMT2A;
Unclassified	HTT; RAB9A; NPC1; LMNA; FABP4; MAPT; HBB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510

Showing 1 to 10 of 24 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	8.532E-08	2.322E-04	BCL2, CA2, FABP4, KMT2A, MAPK1, NPC1, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.407E-07	3.275E-04	CA14, CA2, CA7, HBB
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.521E-06	2.644E-03	ALPL, BRCA1, CASP7, MAPK1, NFKB1, NPC1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	3.101E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	6.936E-06	4.167E-03	BRCA1, CASP7, MAPK1, NFKB1, TP53, TSHR
BP	GO:0009987; cellular process	GO:0010821; regulation of mitochondrion organization	7.436E-06	4.167E-03	BCL2, HTT, LMNA, MAPT, TP53
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	7.464E-06	4.167E-03	BCL2, BRCA1, HTT, LMNA
BP	GO:0051179; localization	GO:0051050; positive regulation of transport	1.364E-05	6.027E-03	BCL2, CA2, CASP1, HTT, KMT2A, MAPK1, RAB9A, TP53
BP	GO:0009987; cellular process	GO:0071356; cellular response to tumor necrosis factor	1.413E-05	6.032E-03	BRCA1, FABP4, MAPK1, NFKB1
BP	GO:0050896; response to stimulus	GO:0035094; response to nicotine	1.742E-05	7.293E-03	BCL2, MAPK1, NFKB1

Showing 1 to 10 of 17 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.021E-06	7.403E-05	CA2, CA7, CA14
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.741E-03	9.243E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.083E-03	9.789E-03	CYP2C9, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.493E-04	3.127E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.443E-03	9.789E-03	CYP2C9, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.194E-05	2.884E-04	BCL2, MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	4.555E-05	5.504E-04	BCL2, MAPK1, BRCA1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.244E-04	1.787E-03	MAPK1, MAPT, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	3.012E-04	2.080E-03	CASP7, MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.482E-04	1.799E-03	BCL2, MAPK1, NFKB1

Showing 1 to 10 of 51 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;

Showing 1 to 10 of 45 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cinnamomum aromaticum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities