CMAUP Plant Collective Molecular Activities

Plant Name: Trigonella foenum-graecum

Taxonomic Information:

Plant ID: NPO8210
Plant Latin Name: Trigonella foenum-graecum
Taxonomy Genus: Trigonella
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 78534
Plant-of-the-World-Online: 523957-1

Used in Medicines:

Country/Region:

Canada; Israel; Turkmenistan; Algeria; India; Indonesia; Lebanon; Jordan; Chile; Argentina; Iraq; Spain

Traditional Medicine System:

Indian Folk; Unani; Ayurveda; Siddha

Medicinal Functions:

Anticholesterolemic; Antiinflammatory; Antiphlogistic; Antitumor; Appetizer; Cardiotonic; Carminative; Demulcent; Deobstruent; Diuretic; Emollient; Expectorant; Febrifuge; Galactogogue; Hypoglycaemic; Hypotensive; Laxative; Parasiticide; Restorative

Geographical Distribution:

Canada; Afghanistan; Italy; Bangladesh; Sudan; Kuwait; Mali; France; Ethiopia; Argentina; Turkmenistan; Israel; Lebanon; Iran; Algeria; Turkey; Jordan; Zimbabwe; China; Chile; Belgium; Germany; Iraq; Spain; Ukraine; Nepal; Libya; Oman; Tanzania; Indonesia; Saudi Arabia; Tajikistan; Morocco; Kenya; Switzerland; Yemen; Russia; Bulgaria; Pakistan; Romania; Albania; Portugal; Myanmar; Tunisia; Cyprus; India; Uzbekistan; Austria; Mozambique; Greece; Hungary; Fiji

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; BLM;
Lyase	CA7; CA4; CA12; CA9;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLCO1B1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP19A1; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-06	CA12, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.003E-08	1.093E-04	CA12, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	1.673E-04	CA12, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	1.937E-07	7.394E-04	BLM, CA12, CA4, CA7, CA9, CYP19A1, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.790E-06	5.568E-03	CYP19A1, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.924E-06	7.076E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.224E-06	9.198E-03	CYP19A1, CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.556E-10	2.596E-08	CA12, CA4, CA7, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	6.671E-03	CYP2C9, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CA9;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases