CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1990000; amyloid fibril formation	4.142E-04	5.340E-01	MAPT
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	4.659E-04	5.340E-01	MAPT
CC	GO:0044464; cell part	GO:0030673; axolemma	8.283E-04	6.997E-01	MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.469E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	5.695E-04	5.905E-01	MAPT
MF	GO:0005488; binding	GO:0034185; apolipoprotein binding	8.283E-04	6.997E-01	MAPT
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	1.450E-03	8.306E-01	MAPT
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.657E-03	9.018E-01	MAPT
MF	GO:0005488; binding	GO:0042803; protein homodimerization activity	4.116E-02	1.000E+00	MAPT

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.275E-02	1.275E-02	MAPT
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	8.400E-03	1.275E-02	MAPT

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Symplocos chinensis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities