CMAUP Plant Collective Molecular Activities

Plant Name: Citrullus lanatus subsp. vulgaris

Taxonomic Information:

Plant ID: NPO8108.1
Plant Latin Name: Citrullus lanatus subsp. vulgaris
Taxonomy Genus: Citrullus
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 3654
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Jordan; South Korea; Indonesia; India

Traditional Medicine System:

Medicinal Functions:

Cardiac; Demulcent; Diuretic; Enuresis; Febrifuge; Pectoral; Purgative; Tonic; Vermifuge

Geographical Distribution:

Jordan; South Korea; Indonesia; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GABBR1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM;
GABA-A receptor	GABRR1;
Plant homeodomain	KMT2A;
SLC superfamily of solute carriers	SLC6A1; SLC6A11;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
SLC superfamily of solute carriers	SLC6A1	GABA transporter 1	P30531	CHEMBL1903
SLC superfamily of solute carriers	SLC6A11	GABA transporter 3	P48066	CHEMBL5208
Small molecule receptor (family C GPCR)	GABBR1	GABA-B receptor 1	Q9UBS5	CHEMBL2064
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005332; gamma-aminobutyric acid:sodium symporter activity	9.002E-07	1.633E-02	SLC6A1, SLC6A11
BP	GO:0065007; biological regulation	GO:0045761; regulation of adenylate cyclase activity	1.473E-04	2.291E-01	GABBR1, TSHR
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	2.415E-04	2.811E-01	GABBR1, GABRR1, TSHR
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	3.184E-03	7.666E-01	GABBR1, GABRR1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	2.416E-08	4.591E-07	GABBR1, GABRR1, SLC6A11, SLC6A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.398E-04	1.328E-03	GABBR1, GABRR1, TSHR
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	5.632E-04	3.567E-03	GABBR1, GABRR1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.652E-03	1.259E-02	GABBR1, TSHR
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	1.589E-02	4.215E-02	GABRR1
09100 Metabolism	09105 Amino acid metabolism	hsa00310	Lysine degradation	2.062E-02	4.215E-02	KMT2A
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	2.101E-02	4.215E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.219E-02	4.215E-02	TSHR
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.154E-02	4.215E-02	BLM
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	2.101E-02	4.215E-02	BLM

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases