CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; POLB;
Lyase	CA2;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; HTT; FABP3; FABP2; FABP4; LMNA; FABP5;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Showing 1 to 10 of 18 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	8.346E-09	4.543E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.611E-08	6.434E-05	CYP1A2, CYP2C19, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.765E-07	3.494E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	7.140E-06	6.653E-03	CA2, CYP1A2, FABP5, HTT, LMNA, POLB, PPARA, PPARD, SMN1, SMN2, TLR2, TSHR
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	7.965E-06	6.937E-03	CYP1A2, CYP2C19, FABP3, PPARA, PPARD
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.015E-05	3.194E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	7.104E-05	3.597E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0005737; cytoplasm	1.055E-04	4.785E-02	CA2, CYP3A4, FABP3, FABP4, FABP5, HTT, MAPT, POLB, SMN1, SMN2, TDP1, TLR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.494E-06	5.696E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.115E-05	8.996E-03	CYP1A2, CYP2C19, CYP3A4

Showing 1 to 10 of 13 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	7.844E-05	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.660E-05	7.321E-04	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.369E-03	1.369E-02	CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.716E-03	1.439E-02	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.159E-03	1.439E-02	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.741E-03	2.845E-02	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.535E-11	2.121E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.277E-03	1.369E-02	FABP4, TSHR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.043E-03	1.439E-02	CA2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.139E-05	9.208E-04	CYP1A2, CYP3A4, CYP2C19

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Showing 1 to 10 of 11 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Gypsophila licentiana hand.-mazz.

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities