CMAUP Plant Collective Molecular Activities

Plant Name: Austrocedrus chilensis

Taxonomic Information:

Plant ID: NPO7986
Plant Latin Name: Austrocedrus chilensis
Taxonomy Genus: Austrocedrus
Taxonomy Family: Cupressaceae

Plant External Links:

NCBI TaxonomyDB: 103964
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Argentina; Chile

Traditional Medicine System:

Geographical Distribution:

Argentina; Chile

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; P4HB; AKR1B1; POLB;
Hydrolase	GAA;
Lysine demethylase	KDM4E;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.171E-06	9.083E-02	AKR1B1, CYP3A4, GAA, KDM4E, P4HB
BP	GO:0008152; metabolic process	GO:0070988; demethylation	1.907E-04	4.384E-01	CYP3A4, KDM4E
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	2.039E-04	4.384E-01	AKR1B1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0016491; oxidoreductase activity	6.464E-05	4.384E-01	AKR1B1, CYP3A4, KDM4E, P4HB
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	1.759E-03	5.715E-01	AKR1B1, CYP3A4, GAA, KDM4E, P4HB, POLB, TDP1
CC	GO:0044464; cell part	GO:0005764; lysosome	4.017E-03	8.366E-01	AKR1B1, GAA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.546E-05	8.638E-04	GAA, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.944E-02	3.430E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.115E-02	3.430E-02	AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.599E-02	3.430E-02	CYP3A4
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.149E-02	3.430E-02	POLB
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.047E-02	3.430E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.013E-02	3.430E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.253E-02	3.430E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.391E-02	3.430E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.459E-02	3.430E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases