Plant Name: Pentadesma butyracea
Taxonomic Information:
Plant ID: NPO7920
Plant Latin Name: Pentadesma butyracea
Taxonomy Genus: Pentadesma
Taxonomy Family: Clusiaceae
Plant External Links:
NCBI TaxonomyDB:
198785
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALOX12; IDH1; ALOX15; USP2; | |
| XBP1; MAPT; | |
| FASN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | CHEMBL2007625 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Transferase | FASN | Fatty acid synthase | P49327 | CHEMBL4158 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 1.930E-07 | 2.801E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 1.930E-07 | 2.801E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 2.176E-07 | 2.961E-04 | ALOX12, ALOX15, CYP2C19, CYP2C9, FASN, IDH1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.531E-07 | 6.302E-04 | ALOX12, ALOX15, CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 5.788E-07 | 6.302E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 5.788E-07 | 6.302E-04 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 7.395E-07 | 7.667E-04 | ALOX12, ALOX15, CYP2C19, CYP2C9, FASN, IDH1 |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 1.928E-06 | 1.680E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.892E-06 | 2.332E-03 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.667E-06 | 5.551E-03 | CYP2C19, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.271E-05 | 7.685E-03 | CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 2.615E-05 | 1.460E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0048037; cofactor binding | 4.403E-05 | 2.283E-02 | CYP2C19, CYP2C9, FASN, IDH1 |
| CC | GO:0044464; cell part | GO:0099568; cytoplasmic region | 3.805E-03 | 4.962E-01 | MAPT, USP2 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 7.311E-03 | 7.257E-01 | CYP2C19, CYP2C9, XBP1 |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 7.432E-03 | 7.257E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.042E-08 | 2.606E-07 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.149E-07 | 1.436E-06 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.289E-07 | 1.907E-06 | CYP2C9, ALOX15, CYP2C19 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 3.989E-06 | 2.493E-05 | CYP2C9, FASN, IDH1, ALOX15, ALOX12, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 4.157E-04 | 2.079E-03 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.867E-04 | 2.445E-03 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09106 Metabolism of other amino acids | hsa00480 | Glutathione metabolism | 2.316E-02 | 5.264E-02 | IDH1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00020 | Citrate cycle (TCA cycle) | 1.342E-02 | 3.728E-02 | IDH1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00061 | Fatty acid biosynthesis | 5.836E-03 | 2.084E-02 | FASN |
| Unclassified | Unclassified | hsa01210 | 2-Oxocarboxylic acid metabolism | 7.626E-03 | 2.383E-02 | IDH1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
