Plant Name: Centaurea amara
Taxonomic Information:
Plant ID: NPO7884
Plant Latin Name: Centaurea amara
Taxonomy Genus: Centaurea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; HTR7; HTR5A; HTR1F; ADRA1A; ADRB2; ADRB3; ADRA1D; ADRA2A; ADRA2B; DRD3; DRD2; HTR4; HTR1B; HTR1D; HTR1E; HTR2B; HTR2A; HTR1A; HTR2C; HTR6; | |
| OPRD1; OPRM1; | |
| BLM; HSD17B10; MPO; | |
| HTR3A; | |
| GABRR1; | |
| KMT2A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Peptide receptor (family A GPCR) | OPRM1 | Mu opioid receptor | P35372 | CHEMBL233 |
| Plant homeodomain | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Small molecule receptor (family A GPCR) | HTR7 | Serotonin 7 (5-HT7) receptor | P34969 | CHEMBL3155 |
Showing 1 to 10 of 29 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway | 4.096E-12 | 1.683E-09 | HTR1A, HTR1B, HTR5A, HTR7 |
| BP | GO:0009987; cellular process | GO:0002031; G-protein coupled receptor internalization | 1.342E-09 | 4.003E-07 | DRD2, DRD3, HTR1B, HTR2B |
| BP | GO:0008152; metabolic process | GO:0010513; positive regulation of phosphatidylinositol biosynthetic process | 3.036E-08 | 7.266E-06 | HTR2A, HTR2B, HTR2C |
| BP | GO:0009987; cellular process | GO:0014059; regulation of dopamine secretion | 8.181E-08 | 1.665E-05 | DRD2, DRD3, HTR1B, HTR2A |
| BP | GO:0065007; biological regulation | GO:0007194; negative regulation of adenylate cyclase activity | 1.431E-07 | 2.757E-05 | ADRA2A, DRD2, DRD3, OPRM1 |
| BP | GO:0009987; cellular process | GO:0070374; positive regulation of ERK1 and ERK2 cascade | 4.074E-07 | 6.877E-05 | ADRA1A, DRD2, HTR2A, HTR2B, HTR2C, OPRM1 |
| BP | GO:0051179; localization | GO:0051209; release of sequestered calcium ion into cytosol | 5.849E-07 | 9.434E-05 | DRD2, HTR2A, HTR2B, HTR2C |
| BP | GO:0023052; signaling | GO:0051967; negative regulation of synaptic transmission, glutamatergic | 1.095E-06 | 1.633E-04 | DRD2, HTR1B, HTR2A |
| BP | GO:0009987; cellular process | GO:0007208; phospholipase C-activating serotonin receptor signaling pathway | 2.176E-06 | 2.779E-04 | HTR2A, HTR2C |
| BP | GO:0007610; behavior | GO:0048148; behavioral response to cocaine | 3.409E-06 | 4.102E-04 | DRD2, DRD3, HTR2A |
Showing 1 to 10 of 55 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 1.008E-40 | 3.527E-39 | OPRD1, HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, ADRA1D, ADRB2, OPRM1, HTR2A, HTR5A, HTR4, ADRA2B, ADRA1A, ADRA2A, HTR6, GABRR1, HTR7, ADRB3, ADORA3, DRD2, DRD3 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04020 | Calcium signaling pathway | 6.930E-16 | 8.085E-15 | HTR6, HTR7, ADRB3, HTR2B, HTR2C, ADRA1D, ADRB2, HTR2A, HTR5A, HTR4, ADRA1A |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 6.723E-12 | 5.882E-11 | HTR6, HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, ADRB2, HTR4, DRD2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04022 | cGMP-PKG signaling pathway | 7.382E-11 | 5.167E-10 | OPRD1, ADRB3, ADORA3, ADRA1D, ADRB2, ADRA2B, ADRA1A, ADRA2A |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 7.640E-06 | 3.496E-05 | HTR2B, HTR2C, HTR2A, DRD2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.634E-22 | 2.860E-21 | HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR3A, HTR2A, HTR5A, HTR4, HTR6, HTR7 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04742 | Taste transduction | 1.871E-09 | 1.091E-08 | HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, HTR3A |
| 09150 Organismal Systems | 09154 Digestive system | hsa04970 | Salivary secretion | 7.992E-06 | 3.496E-05 | ADRB3, ADRA1D, ADRB2, ADRA1A |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.800E-04 | 1.478E-03 | HTR2B, HTR2C, HTR2A |
| 09150 Organismal Systems | 09153 Circulatory system | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.260E-03 | 4.410E-03 | ADRA1D, ADRB2, ADRA1A |
Showing 1 to 10 of 11 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO; |
| A00-B99: Certain infectious and parasitic diseases | Diarrhea | A09, K59.1 | OPRM1; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3; |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | ADRB3; HTR2B; HTR3A; |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | DRD2; |
| C00-D49: Neoplasms | Pediatric cancer | C00-C96 | ADRA1D; |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | ADRB3; OPRD1; |
| C00-D49: Neoplasms | Prostate cancer | C61 | ADRA1A; |
| C00-D49: Neoplasms | Aggressive non-hodgkin's lymphoma | C81, C81-C86, C82-C85, C91-C95 | HTR2C; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | OPRM1; DRD2; |
Showing 1 to 10 of 171 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
