CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	EIF4A1;
Transcription Factor	RELA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	EIF4A1	Eukaryotic initiation factor 4A-I	P60842	CHEMBL2052028
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0033590; response to cobalamin	3.106E-04	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:2000630; positive regulation of miRNA metabolic process	5.177E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071316; cellular response to nicotine	8.282E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071354; cellular response to interleukin-6	1.553E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0010224; response to UV-B	1.863E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0035994; response to muscle stretch	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:0031293; membrane protein intracellular domain proteolysis	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	2.277E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	2.897E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.104E-03	1.000E+00	RELA

Showing 1 to 10 of 38 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.196E-02	1.944E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	6.988E-03	1.944E-02	RELA
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.196E-02	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.287E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	7.287E-03	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	8.880E-03	1.944E-02	RELA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.007E-02	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	8.582E-03	1.944E-02	RELA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.087E-02	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.177E-02	1.944E-02	RELA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pyrola media

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities