CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	RECQL; TDP1; BLM; MIF; PKM; GLO1; ALOX12; HSD17B1; CBR1; AKR1B1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Transient receptor potential channel	TRPA1;
Isomerase	TOP2A;
Protein Kinase	AXL; MET; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR; XDH;
Lysine demethylase	KDM4E;
Metallo protease	MMP12; MMP9; MMP1; MMP2;
Transcription Factor	AHR; HIF1A; NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	LMNA; THPO;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.470E-11	2.635E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.635E-09	1.978E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	6.651E-09	5.570E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	2.123E-08	1.216E-05	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.317E-08	2.517E-05	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.465E-07	5.062E-05	AKR1B1, ALOX12, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, THPO, TSHR
BP	GO:0040011; locomotion	GO:0030334; regulation of cell migration	1.231E-06	3.269E-04	ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, HIF1A, IGF1R, KDR, LMNA, MET, MIF, MMP9, NOX4
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.756E-06	4.068E-04	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	2.873E-06	6.256E-04	GRIK3, GRM1, GRM8
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	3.250E-06	7.008E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.482E-10	9.982E-08	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.216E-07	3.746E-06	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.627E-05	5.987E-04	CYP2C9, CBR1, ALOX12, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.132E-06	3.649E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.199E-07	5.127E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.576E-05	6.605E-04	CYP2C9, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.052E-05	7.240E-04	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.837E-04	2.317E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.002E-04	9.642E-04	CYP1A2, XDH
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.331E-07	5.127E-06	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, TSHR, GRM1, GRIA4

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; MIF;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sinapis alba

Taxonomic Information:

Plant External Links:

Used in Medicines:

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Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities