CMAUP Plant Collective Molecular Activities

Plant Name: Viscum album

Taxonomic Information:

Plant ID: NPO7808
Plant Latin Name: Viscum album
Taxonomy Genus: Viscum
Taxonomy Family: Viscaceae

Plant External Links:

NCBI TaxonomyDB: 3972
Plant-of-the-World-Online: 300881-2

Used in Medicines:

Country/Region:

Turkey; India; Italy; Lithuania; Lebanon; China; South Korea; Iraq

Traditional Medicine System:

Unani; Indian Folk; TCM; Homeopathy; Ayurveda

Medicinal Functions:

Antianxiety; Anticonvulsant; Antidiarrhoeal; Antispasmodic; Cardiac; Cytostatic; Diuretic; Hypotensive; Narcotic; Nervine; Stimulant; Tonic; Vasodilator

Geographical Distribution:

Turkey; Italy; India; Lithuania; France; Norway; Belarus; Algeria; China; Belgium; Germany; Iraq; Spain; Ukraine; Netherlands; Denmark; Poland; United States; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; Lebanon; United Kingdom; Austria; Greece; Hungary; South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL; ALOX15;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	FABP3; FABP4; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	5.313E-07	3.857E-03	FABP3, FABP4, FFAR4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.328E-04	3.320E-03	CYP2C9, ALOX15
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.117E-04	5.294E-03	CYP2C9, ALOX15
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.470E-04	5.294E-03	CYP2C9, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	7.571E-04	5.294E-03	FABP3, FABP4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.978E-03	8.240E-03	CYP2C9, ALOX15
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	5.336E-03	CYP2C9, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases