CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR1B; HTR1D; TAAR1; HTR2B; HTR2A; HTR1A; HTR2C; HTR6; MTNR1B; MTNR1A;
Enzyme_unclassified	ALOX15;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR1B	Serotonin 1b (5-HT1b) receptor	P28222	CHEMBL1898
Small molecule receptor (family A GPCR)	HTR1D	Serotonin 1d (5-HT1d) receptor	P28221	CHEMBL1983
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225

Showing 1 to 10 of 14 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	1.784E-10	1.850E-07	HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7
BP	GO:0023052; signaling	GO:0007268; chemical synaptic transmission	5.264E-10	4.245E-07	HTR1B, HTR1D, HTR2A, HTR2C, HTR6, HTR7, MTNR1B
BP	GO:0007610; behavior	GO:0050795; regulation of behavior	6.661E-10	4.835E-07	HTR1A, HTR1B, HTR1D, HTR2A, HTR2B
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	1.212E-09	7.996E-07	HTR1A, HTR1B, HTR7
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	3.028E-09	1.884E-06	HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	1.949E-07	9.429E-05	ALOX15, HTR2A, HTR2B, HTR2C, THPO
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	4.878E-07	2.168E-04	HTR2A, HTR2C
BP	GO:0032501; multicellular organismal process	GO:0014827; intestine smooth muscle contraction	2.924E-06	1.117E-03	HTR1D, HTR2B
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	4.224E-06	1.484E-03	HTR2A, HTR2B, HTR2C
BP	GO:0050896; response to stimulus	GO:0071502; cellular response to temperature stimulus	4.872E-06	1.658E-03	HTR1B, HTR2B

Showing 1 to 10 of 21 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	5.026E-04	CYP1A2, ALOX15
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.495E-03	7.690E-03	CYP1A2
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.035E-18	2.277E-17	HTR6, MTNR1A, HTR7, MTNR1B, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR2A, TAAR1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	1.047E-07	7.678E-07	HTR6, HTR7, HTR2B, HTR2C, HTR2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	8.805E-06	4.843E-05	HTR6, HTR1D, HTR1A, HTR1B
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.893E-05	1.061E-04	HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.631E-18	8.394E-17	HTR6, HTR7, HTR1D, ALOX15, HTR1A, HTR2B, HTR1B, HTR2C, HTR2A
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	2.427E-05	1.061E-04	HTR1D, HTR1A, HTR1B
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.993E-05	1.255E-04	HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	1.958E-03	4.785E-03	MTNR1A, MTNR1B

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR2C; HTR6;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2A; HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Desmodium gangeticum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities