CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	PIK3CB; PIK3CA; GFER; NQO2;
Lyase	CA2; CA12; CA9; CA14;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Oxidoreductase	PTGS2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.636E-09	8.314E-05	CA12, CA14, CA2, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	9.709E-07	4.228E-03	CA12, CA2, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.744E-11	1.686E-06	CA12, CA14, CA2, CA9

Showing 1 to 3 of 3 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.174E-10	1.151E-08	CA12, CA2, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	4.378E-06	1.430E-04	PIK3CA, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.587E-05	3.621E-04	PIK3CA, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	4.784E-04	2.391E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	1.003E-03	3.071E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04070	Phosphatidylinositol signaling system	1.270E-03	3.111E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.402E-03	3.111E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.895E-03	3.572E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04152	AMPK signaling pathway	2.022E-03	3.669E-03	PIK3CA, PIK3CB
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.321E-03	3.991E-03	PIK3CA, PIK3CB

Showing 1 to 10 of 76 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; NQO2; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIK3CA; PTGS2; PIK3CB; NQO2; CA9;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	PIK3CA; PIK3CB; CA9;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Coprosma lucida

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities