Plant Name: Commiphora myrrha
Taxonomic Information:
Plant ID: NPO7730
Plant Latin Name: Commiphora myrrha
Taxonomy Genus: Commiphora
Taxonomy Family: Burseraceae
Plant External Links:
NCBI TaxonomyDB:
318982
Plant-of-the-World-Online:
127741-1
Used in Medicines:
Country/Region:
China; Iraq; Jordan; IndiaTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; Ayurveda; SiddhaGeographical Distribution:
Eritrea; Yemen; India; Ethiopia; Djibouti; China; Somalia; Kenya; Jordan; Iraq
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| ACHE; | |
| ALDH1A1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 1.949E-04 | 4.026E-01 | ACHE, ALDH1A1, CYP3A4 |
| MF | GO:0005488; binding | GO:0042562; hormone binding | 1.897E-04 | 4.026E-01 | ACHE, ALDH1A1 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 5.177E-04 | 4.175E-01 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 5.177E-04 | 4.175E-01 | ACHE |
| CC | GO:0044464; cell part | GO:0009986; cell surface | 7.429E-03 | 1.000E+00 | ACHE, TSHR |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | LMNA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.723E-02 | 1.000E+00 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.034E-04 | 2.067E-03 | ALDH1A1, CYP3A4 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.318E-02 | 3.137E-02 | TSHR |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.713E-02 | 3.137E-02 | CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.442E-02 | 3.137E-02 | CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.763E-02 | 3.137E-02 | TSHR |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.763E-02 | 3.137E-02 | CYP3A4 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 2.230E-02 | 3.137E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.058E-02 | 3.137E-02 | LMNA |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.033E-02 | 3.137E-02 | CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 2.353E-02 | 3.137E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
