CMAUP Plant Collective Molecular Activities

Plant Name: Asphodelus tenuifolius

Taxonomic Information:

Plant ID: NPO759
Plant Latin Name: Asphodelus tenuifolius
Taxonomy Genus: Asphodelus
Taxonomy Family: Asphodelaceae

Plant External Links:

NCBI TaxonomyDB: 1423376
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India; Algeria

Traditional Medicine System:

Indian Folk; Unani

Geographical Distribution:

India; Algeria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	AURKB; AURKA; CDK8; KDR;
Lyase	CA2; CA14; CA7; CA4; CA12;
Enzyme_unclassified	GFER;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.009E-13	8.730E-09	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.930E-11	5.367E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.432E-10	1.039E-06	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.398E-09	6.088E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.367E-08	4.251E-05	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.442E-08	9.370E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	6.647E-07	9.457E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.647E-07	9.457E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.688E-06	1.414E-03	CA2, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	2.373E-06	1.845E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.374E-06	2.370E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.764E-06	3.586E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	5.621E-06	3.586E-03	AURKA, AURKB
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	4.829E-03	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	8.428E-06	4.829E-03	AURKA, AURKB
BP	GO:0032502; developmental process	GO:0048513; animal organ development	1.374E-05	7.479E-03	AURKA, CA2, CYP1A1, CYP1A2, GFER, HIF1A, KDR
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.572E-05	8.149E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.937E-13	2.428E-11	CA12, CA2, CA4, CA7, CA14
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.461E-07	6.057E-06	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.316E-06	3.869E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.027E-05	8.989E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.057E-05	1.440E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.299E-04	2.756E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.316E-04	7.678E-04	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.107E-04	1.053E-03	CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.063E-03	4.133E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.196E-03	4.188E-03	CYP1A2, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
C00-D49: Neoplasms	AML	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR; HIF1A;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR; HIF1A;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases