Plant Name: Ixora chinensis
Taxonomic Information:
Plant ID: NPO7510
Plant Latin Name: Ixora chinensis
Taxonomy Genus: Ixora
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
591727
Plant-of-the-World-Online:
753834-1
Used in Medicines:
Country/Region:
Malaysia; Philippines; Indonesia; China; VietnamTraditional Medicine System:
TCMGeographical Distribution:
Bangladesh; Myanmar; Philippines; Indonesia; Cambodia; Malaysia; Vietnam; China; Colombia; Laos; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| ACHE; | |
| NR1H4; | |
| ALOX15; AKR1B10; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006629; lipid metabolic process | 7.281E-05 | 2.349E-01 | ACHE, AKR1B10, ALOX15, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 5.177E-04 | 2.818E-01 | ACHE |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 5.177E-04 | 2.818E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 7.764E-04 | 3.315E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 7.764E-04 | 3.315E-01 | ALOX15 |
| CC | GO:0044425; membrane part | GO:0019897; extrinsic component of plasma membrane | 2.664E-02 | 1.000E+00 | ALOX15 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 7.230E-03 | 2.466E-02 | ALOX15 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 8.969E-03 | 2.466E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 7.478E-03 | 2.466E-02 | AKR1B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.466E-02 | 2.770E-02 | AKR1B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.541E-02 | 2.770E-02 | ALOX15 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 7.975E-03 | 2.466E-02 | AKR1B10 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 2.745E-02 | 3.046E-02 | ACHE |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.763E-02 | 2.770E-02 | NR1H4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.769E-02 | 3.046E-02 | ALOX15 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 2.353E-02 | 3.046E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
