CMAUP Plant Collective Molecular Activities

Plant Name: Rubus trifidus

Taxonomic Information:

Plant ID: NPO745
Plant Latin Name: Rubus trifidus
Taxonomy Genus: Rubus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 75096
Plant-of-the-World-Online: 927379-1

Used in Medicines:

Unknown.

Geographical Distribution:

Japan; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Oxidoreductase	HMGCR;
Transcription Factor	TP53;
Unclassified	MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	5.440E-08	1.184E-03	HMGCR, MAPT, TP53
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.823E-07	3.501E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.205E-06	6.562E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.687E-06	7.349E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006720; isoprenoid metabolic process	5.217E-06	1.154E-02	CYP1A2, CYP3A4, HMGCR
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.300E-06	1.154E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	5.300E-06	1.154E-02	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.028E-05	3.681E-02	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	2.605E-05	4.051E-02	CYP1A2, CYP3A4
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	7.913E-05	1.014E-01	MAPT, TP53
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.913E-05	1.014E-01	CYP1A2, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.939E-03	4.444E-01	CYP1A2, CYP3A4, HMGCR
CC	GO:0044464; cell part	GO:0030673; axolemma	4.960E-03	6.586E-01	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.034E-05	1.517E-03	CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.231E-04	1.627E-03	CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.547E-04	1.627E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.744E-04	1.627E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.953E-04	1.627E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.847E-04	1.627E-03	HMGCR, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.464E-04	1.760E-03	CYP1A2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.348E-03	1.305E-02	MAPT, TP53
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.116E-03	2.058E-02	CYP1A2, HMGCR, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.499E-03	9.370E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases