CMAUP Plant Collective Molecular Activities

Plant Name: Tribulus terrestris

Taxonomic Information:

Plant ID: NPO7395
Plant Latin Name: Tribulus terrestris
Taxonomy Genus: Tribulus
Taxonomy Family: Zygophyllaceae

Plant External Links:

NCBI TaxonomyDB: 210369
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India; Algeria

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCM; Homeopathy

Medicinal Functions:

Abortifacient; Alterative; Anthelmintic; Aphrodisiac; Carminative; Demulcent; Diuretic; Galactogogue; Infertility; Pectoral

Geographical Distribution:

India; China; Algeria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C;
Protein Kinase	DYRK2; DYRK3; CLK1; DYRK1A; DYRK1B; HASPIN;
Oxidoreductase	MAOA;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Protein Kinase	DYRK2	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Q92630	CHEMBL4376
Protein Kinase	DYRK3	Dual-specificity tyrosine-phosphorylation regulated kinase 3	O43781	CHEMBL4575
Protein Kinase	CLK1	Dual specificty protein kinase CLK1	P49759	CHEMBL4224
Protein Kinase	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Q13627	CHEMBL2292
Protein Kinase	DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Q9Y463	CHEMBL5543
Protein Kinase	HASPIN	Serine/threonine-protein kinase haspin	Q8TF76	CHEMBL1075163
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004712; protein serine/threonine/tyrosine kinase activity	1.738E-11	3.785E-07	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	3.458E-08	2.040E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
MF	GO:0003824; catalytic activity	GO:0004713; protein tyrosine kinase activity	3.017E-08	2.040E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3
MF	GO:0003824; catalytic activity	GO:0004674; protein serine/threonine kinase activity	6.732E-08	2.932E-04	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.121E-04	5.938E-03	MAOA, CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.323E-04	8.853E-03	MAOA, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C;
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; MAOA; MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; MAOA;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C; MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases