CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; ALOX12; NOX4; HSD17B10; POLB;
Protein Kinase	PIM1; FLT3; AURKB; KDR; CDK1; IGF1R; AXL; MET;
Transferase	POLA1; FUT7;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	6.902E-08	1.670E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, NFKB1, PIM1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.082E-06	1.023E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.400E-06	1.089E-03	AURKB, FLT3, IGF1R, KDR, PIM1
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	2.151E-05	9.760E-03	AURKB, CDK1, POLB
MF	GO:0005488; binding	GO:0000166; nucleotide binding	1.503E-05	8.150E-03	AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MET, NOX4, PIM1, POLA1
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	2.132E-05	9.760E-03	FLT3, KDR

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	6.788E-05	2.240E-03	KDR, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	3.241E-04	6.418E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.417E-05	1.360E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.747E-05	1.360E-03	FLT3, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.914E-04	4.736E-03	PIM1, CYP1B1, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.758E-04	9.501E-03	FLT3, MET, NFKB1, IGF1R

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Viral infections	B01, B02, A60, B00, B27, G05.1, P35.2	POLA1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;

Showing 1 to 10 of 70 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Acacia arabica

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities