CMAUP Plant Collective Molecular Activities

Plant Name: Senecio brasiliensis

Taxonomic Information:

Plant ID: NPO7336
Plant Latin Name: Senecio brasiliensis
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 183623
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Hydrolase	GAA;
Lyase	CA2; CA1; CA7; CA4; CA6; CA12; CA9; CA14;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOA;
Enzyme_unclassified	AKR1B10;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.282E-08	4.969E-05	CA1, CA12, CA2, CA4, CA6, CA7, CA9, NR1H4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	2.124E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.463E-06	2.124E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.463E-06	2.124E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	7.305E-06	8.372E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.019E-23	8.751E-19	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.098E-18	1.195E-14	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.428E-16	6.217E-13	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.188E-05	2.269E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.149E-22	3.101E-21	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.142E-04	1.541E-03	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.957E-04	1.762E-03	AKR1B10, GAA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.100E-03	7.425E-03	CA2, NR1H4
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	1.667E-02	6.221E-02	MAOA
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.874E-02	6.221E-02	CA2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.765E-02	6.221E-02	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.492E-02	6.221E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2.218E-02	6.221E-02	AKR1B10
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2.765E-02	6.221E-02	MAOA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases