CMAUP Plant Collective Molecular Activities

Plant Name: Embelia barbeyana

Taxonomic Information:

Plant ID: NPO7334
Plant Latin Name: Embelia barbeyana
Taxonomy Genus: Embelia
Taxonomy Family: Primulaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Phosphatase	CDC25B;
Protein Kinase	MET; AXL; FLT3; CDK1; MAPK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	ALOX5; TYR;
Enzyme_unclassified	ALOX12; HSD17B2; HSD17B10; NOX4; POLB;
Transcription Factor	AHR;
Unclassified	MPEG1; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A1; CYP1A2; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	MPEG1	Macrophage-expressed gene 1 protein	Q2M385	CHEMBL3414409
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.904E-07	3.132E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.337E-07	3.777E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.142E-06	1.188E-03	ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, TYR
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.552E-06	1.294E-03	ALOX12, ALOX5, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.185E-06	1.445E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	3.318E-06	1.474E-03	ALOX12, CA12, CA7, FABP4, MAPK1, MET, NOX4, NPSR1, NR1H4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.234E-06	1.773E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.234E-06	1.773E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	5.332E-06	2.037E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	6.882E-06	2.341E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.127E-05	3.506E-03	CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.520E-05	4.489E-03	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, NR1H4, PIM1
BP	GO:0032502; developmental process	GO:0007568; aging	1.525E-05	4.489E-03	AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.950E-05	5.514E-03	ALOX12, CDC25B, CDK1, FLT3, IGF1R, KDR, MAPK1, PIM1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.106E-05	5.879E-03	CYP1A1, CYP1A2, CYP1B1, HSD17B2, NR1H4
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	2.731E-05	7.433E-03	ALOX12, IGF1R, KDR, MAPK1, MET, NOX4
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	2.813E-05	7.561E-03	ALOX12, ALOX5
MF	GO:0005488; binding	GO:0020037; heme binding	2.869E-05	7.618E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	3.963E-05	9.716E-03	AXL, CDK1, CYP1B1, FLT3, KDR, MAPK1, MET, NOX4
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	3.934E-05	9.716E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.158E-09	7.451E-07	ALOX5, HSD17B2, CYP1A1, CYP1B1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.063E-06	6.431E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8.724E-06	3.518E-04	CDK1, MAPK1, CDC25B, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.097E-05	6.343E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.311E-05	1.043E-03	PIM1, CYP1B1, MAPK1, MET, CDC25B
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	6.115E-05	1.233E-03	FLT3, PIM1, MAPK1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.180E-04	1.518E-03	MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	9.922E-05	1.518E-03	FLT3, MAPK1, MET
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.506E-04	1.518E-03	KDR, MAPK1, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.478E-04	1.518E-03	KDR, MAPK1, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.747E-04	1.564E-03	KDR, MAPK1, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.281E-04	1.518E-03	CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.334E-04	1.518E-03	MAPK1, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.310E-04	1.783E-03	KDR, MAPK1, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.810E-04	1.564E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.534E-04	3.227E-03	ALOX5, MAPK1, ALOX12
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.020E-03	6.466E-03	ALOX5, HSD17B2, CYP1A2, CYP1A1, ALOX12, TYR, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.069E-03	6.466E-03	KDR, MAPK1, MET, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	5.960E-04	4.007E-03	CDK1, MAPK1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.357E-04	1.783E-03	CA12, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; MAPK1; CDC25B;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
C00-D49: Neoplasms	CLL	NA	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
NA: NA	HIV infections	NA	AHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5; TYR;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MAPK1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; ALOX5;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases