CMAUP Plant Collective Molecular Activities

Plant Name: Fraxinus quadrangulata

Taxonomic Information:

Plant ID: NPO7308
Plant Latin Name: Fraxinus quadrangulata
Taxonomy Genus: Fraxinus
Taxonomy Family: Oleaceae

Plant External Links:

NCBI TaxonomyDB: 56032
Plant-of-the-World-Online: 609183-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

United States; Georgia; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	TDP1; PTGES; NOS2; ALOX15; USP2; BRCA1;
Protein Kinase	PRKCE; MAPK1; EGFR;
Lyase	CA2; CA1; CA12; CA9; CA13; CA5B; CA7; CA4; CA6;
Oxidoreductase	ALOX5; MAOA;
Aspartic protease	BACE1;
Metallo protease	MMP9; ANPEP;
Toll-like and Il-1 receptors	TLR9;
Transcription Factor	HIF1A;
Bromodomain	EP300;
SLC superfamily of solute carriers	SLC22A8; SLC22A6;
Unclassified	HTT; NFE2L2; LMNA; F3; MAPT; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	NOS2	Nitric oxide synthase, inducible	P35228	CHEMBL4481
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	ANPEP	Aminopeptidase N	P15144	CHEMBL1907
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PRKCE	Protein kinase C epsilon	Q02156	CHEMBL3582
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
SLC superfamily of solute carriers	SLC22A8	Solute carrier family 22 member 8	Q8TCC7	CHEMBL1641348
SLC superfamily of solute carriers	SLC22A6	Solute carrier family 22 member 6	Q4U2R8	CHEMBL1641347
Toll-like and Il-1 receptors	TLR9	Toll-like receptor 9	Q9NR96	CHEMBL5804
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	NFE2L2	Nuclear factor erythroid 2-related factor 2	Q16236	CHEMBL1075094
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.651E-09	3.267E-06	ANPEP, BRCA1, CA1, CA12, CA13, CA2, CA4, CA5B, CA6, CA7, CA9, EP300, MMP9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.933E-09	3.508E-06	CA2, CA4, CA9, EGFR, SLC22A6, SLC22A8, TLR9, TSHR
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	3.599E-07	3.135E-04	ALOX5, APP, PTGES
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	5.392E-07	4.048E-04	APP, EGFR, MAPT
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.826E-06	1.053E-03	CA2, CA7, PRKCE
BP	GO:0009987; cellular process	GO:2001234; negative regulation of apoptotic signaling pathway	2.773E-06	1.244E-03	BRCA1, HIF1A, HTT, LMNA, MMP9, NFE2L2
BP	GO:0007610; behavior	GO:0007611; learning or memory	5.158E-06	2.006E-03	APP, EGFR, HIF1A, HTT, MAPK1, MAPT
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	6.958E-06	2.612E-03	APP, BRCA1, CA2, CA9, EGFR, MAPK1, PRKCE, PTGES, SLC22A6
CC	GO:0044464; cell part	GO:0030424; axon	8.608E-06	3.073E-03	APP, BACE1, CA2, HTT, MAPK1, MAPT
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	9.552E-06	3.152E-03	APP, CA2, CA7, HIF1A, HTT, MAPK1, NPSR1, PRKCE
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.070E-05	3.368E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0043627; response to estrogen	1.128E-05	3.432E-03	BRCA1, CA2, EP300, MAPK1
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	1.459E-05	3.922E-03	BRCA1, EGFR, MAPK1, NFE2L2, NOS2, PRKCE
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.741E-05	4.351E-03	ALOX15, BRCA1, HIF1A, HTT, MAPK1, MAPT, MMP9, PRKCE
BP	GO:0051179; localization	GO:0046903; secretion	1.893E-05	4.530E-03	ALOX5, ANPEP, APP, CA2, CA9, HIF1A, MAPK1, MMP9, NOS2, SLC22A6
BP	GO:0009987; cellular process	GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	2.051E-05	4.801E-03	EP300, HIF1A, NFE2L2
BP	GO:0032501; multicellular organismal process	GO:0032640; tumor necrosis factor production	2.137E-05	4.847E-03	APP, TLR9
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	2.478E-05	5.563E-03	APP, CA4, EGFR, HTT, NOS2, PRKCE, PTGES, USP2
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	2.803E-05	6.103E-03	EGFR, MAPK1, MMP9
BP	GO:0008152; metabolic process	GO:0090322; regulation of superoxide metabolic process	2.803E-05	6.103E-03	EGFR, MAPT, NFE2L2
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	3.305E-05	6.986E-03	APP, BRCA1, EGFR, F3, HIF1A, LMNA, MAPK1, MMP9, NOS2, PTGES, TLR9, TSHR
BP	GO:0051179; localization	GO:0042307; positive regulation of protein import into nucleus	3.618E-05	7.363E-03	APP, EGFR, MAPK1, TLR9
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	4.544E-05	8.725E-03	CA2, CA7, HTT, NPSR1, PRKCE
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	4.806E-05	9.101E-03	ALOX15, ALOX5, PTGES
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	5.295E-05	9.671E-03	EGFR, MAPK1, MMP9, NFE2L2
BP	GO:0009987; cellular process	GO:0071345; cellular response to cytokine stimulus	5.307E-05	9.671E-03	ALOX15, BRCA1, HIF1A, MAPK1, NFE2L2, NOS2
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	5.329E-05	9.671E-03	ALOX15, ALOX5
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	5.329E-05	9.671E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.000E-22	1.307E-17	CA1, CA12, CA13, CA2, CA4, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.098E-17	1.195E-13	CA1, CA12, CA13, CA2, CA4, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.183E-17	5.939E-13	CA1, CA12, CA13, CA2, CA4, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.942E-04	2.431E-02	HTT, MAPT
CC	GO:0016020; membrane	GO:0045121; membrane raft	2.273E-04	2.765E-02	APP, BACE1, EGFR, MAPK1, SLC22A6
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.420E-04	2.895E-02	ALOX15, ALOX5, CYP2C9, NOS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.126E-21	3.167E-19	CA12, CA1, CA5B, CA2, CA4, CA7, CA6, CA9, CA13
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.438E-08	4.051E-06	CYP2C9, APP, MAOA, ALOX5, ALOX15, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.256E-06	6.239E-05	NOS2, EP300, MAPK1, HIF1A, EGFR
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.120E-06	1.907E-04	CYP2C9, ALOX5, ALOX15, PTGES
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.609E-05	4.795E-04	PRKCE, EP300, MAPK1, BRCA1, MMP9, EGFR
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	8.134E-05	1.731E-03	NOS2, EP300, MAPK1, HIF1A, MMP9, EGFR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	5.919E-05	1.470E-03	MAPK1, MMP9, EGFR
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	2.461E-04	3.834E-03	EP300, MAPK1, HIF1A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.556E-04	3.834E-03	BACE1, APP, MAPK1, MAPT
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.573E-04	3.834E-03	MAPK1, HIF1A, EGFR
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.235E-04	6.000E-03	MAPK1, HIF1A, MMP9, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	3.185E-04	4.286E-03	NOS2, TLR9, EP300, MAPK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.451E-04	4.286E-03	EP300, MAPK1, EGFR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.932E-04	6.314E-03	EP300, MAPK1, EGFR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8.574E-04	7.097E-03	PRKCE, MAPK1, F3
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	8.090E-04	7.097E-03	MAPK1, MMP9, EGFR
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	8.574E-04	7.097E-03	MAPK1, HIF1A, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	9.333E-04	7.319E-03	NOS2, TLR9, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.344E-03	8.706E-03	NOS2, ALOX5, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.344E-03	8.706E-03	EP300, MAPK1, HIF1A
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	8.221E-04	7.097E-03	CA2, CA4
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	1.135E-03	8.458E-03	MAPK1, EGFR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.310E-03	8.706E-03	CYP2C9, ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; PTGES;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases