Plant Name: Xanthostemon oppositifolius
Taxonomic Information:
Plant ID: NPO7237
Plant Latin Name: Xanthostemon oppositifolius
Taxonomy Genus: Xanthostemon
Taxonomy Family: Myrtaceae
Plant External Links:
NCBI TaxonomyDB:
1619564
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; | |
| ACHE; | |
| PPARA; | |
| TLR2; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 6.752E-07 | 7.351E-03 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.687E-06 | 1.225E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 2.362E-06 | 1.286E-02 | CYP1A2, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 7.417E-06 | 2.019E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 7.417E-06 | 2.019E-02 | CYP1A2, CYP3A4 |
| BP | GO:0002376; immune system process | GO:0001774; microglial cell activation | 1.527E-05 | 3.695E-02 | MAPT, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.838E-05 | 5.617E-02 | CYP1A2, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006706; steroid catabolic process | 3.644E-05 | 5.667E-02 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.106E-04 | 1.417E-01 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0044877; macromolecular complex binding | 2.119E-04 | 2.255E-01 | ACHE, MAPT, PPARA, TLR2 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 1.759E-03 | 3.618E-01 | ACHE, CYP1A2, CYP3A4, MAPT, PPARA, TDP1, TLR2 |
| CC | Unclassified; | GO:0106003; amyloid-beta complex | 3.980E-03 | 4.952E-01 | TLR2 |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 5.785E-03 | 5.942E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.244E-05 | 1.613E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.720E-04 | 2.073E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.161E-04 | 2.073E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.436E-04 | 2.073E-03 | CYP1A2, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.727E-04 | 2.073E-03 | CYP1A2, CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 3.441E-04 | 2.179E-03 | CYP1A2, CYP3A4 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 2.528E-02 | 6.003E-02 | TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.391E-02 | 6.003E-02 | PPARA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.459E-02 | 6.003E-02 | CYP3A4 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.749E-03 | 9.494E-03 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
