CMAUP Plant Collective Molecular Activities

Plant Name: Toddalia asiatica

Taxonomic Information:

Plant ID: NPO7213
Plant Latin Name: Toddalia asiatica
Taxonomy Genus: Toddalia
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 159068
Plant-of-the-World-Online: 775412-1

Used in Medicines:

Country/Region:

Tanzania; India; Rwanda; China; Thailand; Kenya

Traditional Medicine System:

Indian Folk; TCM; Ayurveda; Siddha

Geographical Distribution:

Madagascar; Bangladesh; Sudan; Vietnam; Philippines; Nepal; India; Zimbabwe; Zambia; Mauritius; Ethiopia; Rwanda; China; Mozambique; Swaziland; Thailand; Burundi; Kenya; Tanzania; Malawi; Uganda

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Phosphodiesterase 4	PDE4D;
Enzyme_unclassified	MTOR; ALOX15; ALDH1A1;
Transcription Factor	TP53;
Unclassified	LMNA; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6; CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.161E-10	6.560E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.161E-10	6.560E-07	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.610E-10	7.012E-07	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.383E-09	3.298E-06	ALOX15, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.515E-09	3.298E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.077E-08	1.675E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.878E-08	2.272E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.364E-08	3.662E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.532E-08	4.699E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.997E-07	4.030E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.647E-07	4.991E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	8.881E-07	6.446E-04	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0044281; small molecule metabolic process	1.046E-06	6.899E-04	ALDH1A1, ALOX15, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, MTOR, PDE4D
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.688E-06	1.050E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.042E-16	1.751E-11	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	3.698E-05	1.751E-02	SMN1, SMN2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	3.992E-05	1.850E-02	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, MTOR
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.369E-05	1.982E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	8.550E-05	3.325E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.325E-11	9.935E-10	CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.233E-09	4.623E-08	CYP2C9, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.350E-07	3.375E-06	CYP2C9, CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.162E-07	4.055E-06	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.213E-06	1.516E-05	CYP2C9, CYP2D6, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.461E-07	5.192E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.257E-05	1.347E-04	CYP2C9, ALOX15, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.720E-04	1.612E-03	CYP2C9, CYP1A2, ALOX15, ALDH1A1, CYP2C19, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.063E-03	7.695E-03	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.129E-03	7.695E-03	TP53, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.471E-04	7.059E-03	CYP1A2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	PDE4D;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PDE4D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	PDE4D;
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE4D;
J00-J99: Diseases of the respiratory system	Emphysema	J43	PDE4D;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE4D;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases