CMAUP Plant Collective Molecular Activities

Plant Name: Glycyrrhiza uralensis

Taxonomic Information:

Plant ID: NPO7154
Plant Latin Name: Glycyrrhiza uralensis
Taxonomy Genus: Glycyrrhiza
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 74613
Plant-of-the-World-Online: 496974-1

Used in Medicines:

Country/Region:

Afghanistan; Pakistan; India; China; Thailand; Russia

Traditional Medicine System:

Indian Folk; TCM; Kampo

Medicinal Functions:

Antiphlogistic; Antispasmodic; Antitussive; Cholagogue; Emollient; Expectorant

Geographical Distribution:

Afghanistan; Pakistan; Tajikistan; South Africa; India; Mongolia; China; Thailand; Kazakhstan; Russia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPL; TDP1; BLM; HSD11B1; HSD11B2; PGD; ALOX12; HSD17B1; AKR1B1; HSD17B2; GFER; HSD17B10; USP2; BRCA1; TNKS; TNKS2; APEX1; AOX1;
Protein Phosphatase	PTPN1; CDC25B;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
Protein Kinase	MAPK1; EGFR; CDK6; CSNK2A1;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53; NFKB1; AHR;
Plant homeodomain	KMT2A;
Transferase	FUT7;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	HBB; LMNA; HTT; RAB9A; NPC1; F3; THPO; SIGMAR1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C9; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	P80365	CHEMBL3746
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	7.192E-11	1.305E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.021E-10	1.676E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, HBB
MF	GO:0005488; binding	GO:0005496; steroid binding	3.078E-10	3.943E-07	ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NPC1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.465E-10	9.013E-07	CA12, CA14, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.027E-09	9.725E-07	ALPL, APEX1, BLM, BRCA1, CASP7, CYP1A1, CYP1B1, EGFR, ESR1, MAPK1, NFKB1, NPC1
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.041E-09	1.852E-06	ALOX12, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, HBB
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.477E-09	4.244E-06	CA12, CA14, CA2, CA4, CA7, HBB
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.652E-09	4.244E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	2.066E-08	1.097E-05	AKR1B1, APEX1, BLM, BRCA1, CDK6, CYP1B1, EGFR, MAPK1, NFKB1, TP53
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.969E-08	1.469E-05	BLM, BRCA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, KMT2A, NR1H4, PTPN1, TNKS, TP53
MF	GO:0005488; binding	GO:0020037; heme binding	1.728E-07	5.881E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, HBB
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.255E-07	1.816E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.138E-07	2.188E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	1.266E-06	3.064E-04	AKR1B1, APEX1, CYP1B1, EGFR, MAPK1, TP53
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.436E-06	3.327E-04	AHR, BRCA1, ESR1, ESR2, ESRRA, ESRRB, NR1H4
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	3.736E-06	7.395E-04	BRCA1, ESR1, ESR2, ESRRA, ESRRB, NR1H4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.151E-06	8.143E-04	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.247E-06	1.002E-03	CA12, CA2, CA4, CA7
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.717E-06	1.073E-03	BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, EGFR, HSD11B1, HSD11B2, HSD17B2, RAB9A, SIGMAR1
BP	GO:0050896; response to stimulus	GO:0033273; response to vitamin	6.523E-06	1.194E-03	ALPL, CYP1A1, EGFR, TP53, TYR
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.787E-06	1.231E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	8.802E-06	1.533E-03	CYP19A1, HSD17B1, HSD17B2
MF	GO:0005488; binding	GO:0042802; identical protein binding	9.652E-06	1.655E-03	ACHE, AOX1, BCL2, BLM, CASP1, CSNK2A1, EGFR, ESR1, ESR2, HTT, KMT2A, MAPK1, NFKB1, RAB9A, TP53, TYR, USP2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	1.014E-05	1.698E-03	ESR1, ESR2
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	1.682E-05	2.543E-03	BCL2, BRCA1, CYP1B1, EGFR, HBB, TP53
BP	GO:0065007; biological regulation	GO:1904355; positive regulation of telomere capping	2.074E-05	3.051E-03	MAPK1, TNKS, TNKS2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	2.121E-05	3.079E-03	ACHE, AHR, AKR1B1, APEX1, BCL2, BLM, BRCA1, CA4, CASP1, CASP7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, EGFR, ESR1, ESR2, ESRRA, ESRRB, FUT7, GFER, HSD17B10, HTT, KDM4E, KMT2A, LMNA, MAPK1, NFKB1, NPC1, PGD, PTPN1, RAB9A, SIGMAR1, TDP1, TNKS, TNKS2, TP53, TYR
BP	GO:0050896; response to stimulus	GO:0042542; response to hydrogen peroxide	2.500E-05	3.605E-03	AKR1B1, APEX1, BCL2, CYP1B1, HBB
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.889E-05	4.059E-03	CA2, CA4, EGFR, SLCO1B1, SLCO1B3, TSHR
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.035E-05	4.182E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	3.035E-05	4.182E-03	BCL2, NR1H4
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	3.120E-05	4.194E-03	AHR, AKR1B1, APEX1, BCL2, BLM, BRCA1, CASP7, CDC25B, CDK6, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, HTT, KMT2A, LMNA, MAPK1, NFKB1, NR1H4, TNKS, TP53, USP2
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	3.701E-05	4.797E-03	ACHE, AKR1B1, APEX1, CA4, EGFR, HTT, NPC1, TNKS2, TYR, USP2
BP	GO:0009987; cellular process	GO:0097237; cellular response to toxic substance	4.150E-05	5.316E-03	AKR1B1, APEX1, CYP1B1, NFKB1, TP53
BP	GO:0051179; localization	GO:0051050; positive regulation of transport	4.873E-05	5.961E-03	ACHE, BCL2, CA2, CASP1, CYP19A1, EGFR, HTT, KMT2A, MAPK1, NR1H4, RAB9A, TP53
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.327E-05	6.409E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	6.057E-05	6.898E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.057E-05	6.898E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	6.057E-05	6.898E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.057E-05	6.898E-03	CYP1A2, CYP2C9
MF	GO:0005488; binding	GO:0003684; damaged DNA binding	6.339E-05	7.078E-03	APEX1, BLM, BRCA1, TP53
BP	GO:0050896; response to stimulus	GO:0048545; response to steroid hormone	7.181E-05	7.937E-03	ALPL, BCL2, CA2, EGFR, HSD11B2, NPC1
BP	GO:0050896; response to stimulus	GO:0043627; response to estrogen	8.873E-05	9.612E-03	BRCA1, CA2, ESR1, MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.064E-12	1.523E-09	HSD11B1, HSD11B2, HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.460E-09	1.226E-07	CA12, CA2, CA4, CA7, CA14
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.167E-07	1.330E-05	CDK6, BCL2, CYP1B1, MAPK1, BRCA1, TP53, EGFR, NFKB1, CDC25B
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.622E-07	1.553E-05	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.757E-07	2.172E-05	AKR1B1, ALOX12, CYP2C19, PGD, TYR, CYP19A1, HSD17B10, HSD11B1, CYP2C9, FUT7, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, AOX1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.019E-07	1.131E-05	HSD11B1, CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.877E-06	4.505E-05	CDK6, MAPK1, TP53, EGFR, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.706E-06	8.784E-05	CASP7, LMNA, BCL2, MAPK1, TP53, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.103E-06	6.515E-05	HSD11B1, CYP2C9, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	8.254E-06	1.261E-04	BCL2, MAPK1, TP53, EGFR, NFKB1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	7.036E-06	1.182E-04	CYP1A2, CYP1A1, AOX1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	2.725E-05	3.815E-04	CDK6, MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	4.919E-05	5.903E-04	CDK6, MAPK1, TP53, EGFR
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	6.403E-05	6.273E-04	CDK6, CSNK2A1, RAB9A, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	8.662E-05	6.273E-04	CDK6, BCL2, MAPK1, BRCA1, TP53, EGFR, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.919E-05	5.903E-04	CYP2C9, CYP1A2, CYP1A1, AOX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.224E-05	6.273E-04	CYP2C9, CYP1A2, AOX1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.963E-05	6.273E-04	CDK6, MAPK1, TP53, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	7.355E-05	6.273E-04	MAPK1, ESR1, NFKB1, ESR2
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	8.962E-05	6.273E-04	CDK6, BCL2, MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.763E-05	6.273E-04	CDK6, MAPK1, TP53, NFKB1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.963E-05	6.273E-04	SLCO1B1, CA2, SLCO1B3, NR1H4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	8.188E-05	6.273E-04	PTPN1, CSNK2A1, MAPK1, EGFR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.730E-04	1.611E-03	BCL2, MAPK1, F3, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	8.629E-05	6.273E-04	CASP7, CASP1, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	2.528E-04	1.573E-03	MAPK1, ESR1, EGFR, ESR2
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.470E-04	9.497E-04	CDK6, BCL2, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.942E-04	1.648E-03	BCL2, MAPK1, EGFR, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.048E-04	2.194E-03	CYP2C9, MAPK1, ALOX12, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	5.256E-04	2.625E-03	BCL2, MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.256E-04	2.625E-03	BCL2, MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.160E-03	4.720E-03	MAPK1, TP53, EGFR, NFKB1, CDC25B
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.418E-03	5.542E-03	CDK6, BCL2, MAPK1, TP53, EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	7.736E-04	3.420E-03	MAPK1, TP53, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	5.626E-04	2.701E-03	MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.780E-04	1.611E-03	MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	9.419E-04	3.956E-03	BCL2, MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	6.635E-04	3.096E-03	CASP7, CASP1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.180E-03	4.720E-03	MAPK1, TP53, EGFR
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	5.313E-04	2.625E-03	BCL2, CASP1, TP53
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	7.368E-04	3.345E-03	CASP1, MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.419E-04	3.956E-03	CYP2C9, ALOX12, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.418E-03	9.026E-03	CASP1, MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.787E-05	6.577E-04	CYP2C9, CYP1A2, CYP2C19
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.294E-03	8.759E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	ESRRA;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1; PTPN1; AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA;
J00-J99: Diseases of the respiratory system	Asthma	J45	ESRRA;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; HSD11B1;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR; F3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Colon cancer	C50	EGFR; ALPL;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	EGFR; TP53;
NA: NA	Colour dead tissues	NA	PTPN1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; ESRRA;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR; CYP19A1;
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1;
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Gastric cancer	C16	EGFR;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR; BCL2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
NA: NA	Postmenopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; EGFR; CYP19A1; BCL2;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1; EGFR;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; CSNK2A1; NFKB1; ACHE; MAPK1; EGFR; TP53; CDC25B; BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ESRRA;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ESRRA; CASP1; AKR1B1; TYR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1; HSD11B2; NFKB1; PTPN1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	EGFR; TYR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
NA: NA	Menopausal disorder	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; EGFR; TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	EGFR; AKR1B1; TP53;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR; BCL2;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; EGFR; BCL2;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Lymphoma	C81-C86	EGFR; BCL2;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR;
C00-D49: Neoplasms	Glioma	C71	EGFR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1; PTPN1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1; ESRRA;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; BCL2;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA; EGFR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases