Plant Name: Trichocolea tomentella
Taxonomic Information:
Plant ID: NPO7049
Plant Latin Name: Trichocolea tomentella
Taxonomy Genus: Trichocolea
Taxonomy Family: Trichocoleaceae
Plant External Links:
NCBI TaxonomyDB:
53022
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; HSD17B10; | |
| GAA; | |
| NFKB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0000023; maltose metabolic process | 6.212E-04 | 7.512E-01 | GAA |
| BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 1.206E-03 | 7.512E-01 | ALPL, NFKB1 |
| CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 1.449E-03 | 7.512E-01 | NFKB1 |
| MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 4.141E-04 | 7.512E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 6.212E-04 | 7.512E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0004558; alpha-1,4-glucosidase activity | 8.281E-04 | 7.512E-01 | GAA |
| MF | GO:0003824; catalytic activity | GO:0004035; alkaline phosphatase activity | 1.242E-03 | 7.512E-01 | ALPL |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.274E-02 | 3.785E-02 | NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.432E-02 | 3.785E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 1.452E-02 | 3.785E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.294E-02 | 3.785E-02 | NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.393E-02 | 3.785E-02 | NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.452E-02 | 3.785E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.452E-02 | 3.785E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 1.393E-02 | 3.785E-02 | NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.768E-02 | 3.785E-02 | NFKB1 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.438E-02 | 3.785E-02 | GAA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
