Plant Name: Cistanche tubulosa
Taxonomic Information:
Plant ID: NPO6964
Plant Latin Name: Cistanche tubulosa
Taxonomy Genus: Cistanche
Taxonomy Family: Orobanchaceae
Plant External Links:
NCBI TaxonomyDB:
161397
Plant-of-the-World-Online:
661974-1
Used in Medicines:
Country/Region:
China; Israel; Jordan; IndiaTraditional Medicine System:
Indian Folk; TCMGeographical Distribution:
Afghanistan; Turkmenistan; Sudan; Ethiopia; Israel; Iran; China; Jordan; Iraq; Kazakhstan; Eritrea; Libya; Oman; Tanzania; United States; Yemen; Pakistan; Chad; Egypt; India; Mozambique; Kenya
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| TSHR; | |
| PTPN1; PTPN2; ACP1; PTPRF; | |
| RECQL; HSD11B1; AKR1B10; HSD17B10; ALOX15; | |
| PRKCA; | |
| CA2; CA1; CA12; CA5B; CA5A; CA6; | |
| RORC; | |
| NR1H4; | |
| MMP12; MMP2; | |
| SLCO1B3; SLCO1B1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.220E-14 | 2.657E-10 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.666E-12 | 4.353E-08 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.680E-11 | 9.143E-08 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 8.952E-11 | 3.249E-07 | CA1, CA12, CA2, CA5A, CA5B, CA6, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 4.821E-06 | 7.498E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.821E-06 | 7.498E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 7.560E-06 | 1.034E-02 | ACP1, PTPN1, PTPN2, PTPRF |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 7.598E-06 | 1.034E-02 | NR1H4, SLCO1B1, SLCO1B3 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 2.405E-05 | 2.618E-02 | CA1, CA2 |
| MF | GO:0003824; catalytic activity | GO:0004726; non-membrane spanning protein tyrosine phosphatase activity | 4.482E-05 | 4.066E-02 | ACP1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.446E-14 | 2.225E-12 | CA12, CA1, CA5B, CA2, CA5A, CA6 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.456E-08 | 1.118E-06 | SLCO1B1, CA2, SLCO1B3, NR1H4, CYP3A4 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.055E-04 | 3.199E-03 | PTPN1, ACP1, PTPRF |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.966E-04 | 1.357E-02 | ALOX15, CYP3A4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 3.834E-03 | 4.362E-02 | CA2, PRKCA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.376E-03 | 4.323E-02 | HSD11B1, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 3.536E-03 | 4.362E-02 | PRKCA, TSHR |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.734E-03 | 4.362E-02 | HSD11B1, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 5.738E-03 | 5.222E-02 | MMP2, PRKCA |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 4.686E-03 | 4.738E-02 | HSD11B1, CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
