CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA5B; CA5A; CA6; CA12;
Transcription Factor	RELA;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 7 of 7 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.525E-13	3.838E-09	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.015E-12	7.366E-09	CA1, CA12, CA5A, CA5B, CA6
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	2.534E-03	1.000E+00	RELA
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.554E-06	6.178E-03	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.813E-15	6.126E-11	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0035326; enhancer binding	3.744E-02	1.000E+00	RELA
MF	GO:0005488; binding	GO:0042826; histone deacetylase binding	3.849E-02	1.000E+00	RELA

Showing 1 to 7 of 7 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.871E-15	2.679E-13	CA12, CA1, CA5B, CA5A, CA6
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	3.788E-02	6.127E-02	RELA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	9.984E-04	2.746E-02	LMNA, RELA
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	2.425E-02	6.127E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.074E-02	6.127E-02	RELA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2.562E-02	6.127E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.870E-02	6.127E-02	LMNA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3.482E-02	6.127E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	2.972E-02	6.127E-02	RELA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.754E-02	6.127E-02	RELA

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Euphorbia jolkinii

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities