CMAUP Plant Collective Molecular Activities

Plant Name: Alpinia blepharocalyx

Taxonomic Information:

Plant ID: NPO6836
Plant Latin Name: Alpinia blepharocalyx
Taxonomy Genus: Alpinia
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: 105668
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1; TSHR;
Lyase	CA2; CA14; CA7; CA12; CA1; CA9;
Enzyme_unclassified	HSD17B3; ALDH1A1;
Transcription Factor	TP53;
Unclassified	F3; LMNA; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HSD17B3	Estradiol 17-beta-dehydrogenase 3	P37058	CHEMBL4234
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.827E-13	5.256E-09	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.988E-11	2.172E-07	CA1, CA12, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.688E-06	4.594E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.463E-16	7.540E-12	CA1, CA12, CA14, CA2, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.944E-16	4.097E-14	CA12, CA1, CA2, CA7, CA9, CA14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Cancer	C00-C96	TP53; CA1; CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; CA9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases