CMAUP Plant Collective Molecular Activities

Plant Name: Pseudostellaria heterophylla

Taxonomic Information:

Plant ID: NPO6715
Plant Latin Name: Pseudostellaria heterophylla
Taxonomy Genus: Pseudostellaria
Taxonomy Family: Caryophyllaceae

Plant External Links:

NCBI TaxonomyDB: 418402
Plant-of-the-World-Online: 156276-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Japan; China; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Enzyme_unclassified	CDA; RECQL; ADK; NOX4;
Protein Kinase	CDK8; FLT3;
Lyase	CA4; CA12; CA7;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP12;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.748E-10	3.806E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	8.241E-10	6.515E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.945E-09	2.153E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.314E-08	1.203E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	7.942E-08	2.471E-04	ADORA1, ADORA2A, ADORA3
MF	GO:0005488; binding	GO:0020037; heme binding	1.691E-07	4.091E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.285E-07	7.775E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.659E-06	2.408E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.659E-06	2.408E-03	CYP1A1, CYP1A2, CYP1B1
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	3.054E-06	2.789E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.351E-06	3.384E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19, NR1H4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.104E-06	4.153E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.631E-06	4.247E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.093E-05	6.431E-03	CA12, CA4, CA7, CDA, MMP12, NR1H4, RORC
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.224E-05	7.011E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.524E-05	8.296E-03	CYP1A2, CYP2C19
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.981E-05	9.177E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.210E-06	2.721E-05	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.252E-06	1.238E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.763E-07	2.593E-05	CA12, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.548E-05	2.866E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.086E-05	4.578E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.131E-03	7.269E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.795E-04	2.846E-03	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.020E-03	9.635E-03	FLT3, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.903E-03	9.635E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.141E-03	9.635E-03	CYP1A2, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	AML	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; CDA;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Breast cancer	C50	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; ADORA1; ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	FLT3; HIF1A; ADORA3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; ADORA2A;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases