CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Toll-like and Il-1 receptors	TLR2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.329E-10	7.250E-06	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.660E-09	3.985E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006690; icosanoid metabolic process	2.997E-06	6.621E-03	CYP2C19, CYP2C9, TLR2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.614E-06	6.621E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.953E-06	6.621E-03	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	5.300E-06	7.625E-03	CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.939E-03	4.180E-01	CYP2C19, CYP2C9, CYP3A4
CC	Unclassified;	GO:0106003; amyloid-beta complex	3.412E-03	6.041E-01	TLR2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	4.354E-03	6.677E-01	CYP2C19, CYP2C9, CYP3A4, PPARA, TDP1, TLR2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.614E-03	6.941E-01	CYP2C19, CYP2C9, CYP3A4, TLR2

Showing 1 to 10 of 15 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.466E-08	1.858E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.802E-07	1.326E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.407E-04	1.052E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.547E-04	1.052E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.953E-04	1.106E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.594E-04	2.232E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.052E-02	4.341E-02	PPARA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.317E-06	1.492E-05	CYP2C9, CYP3A4, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	2.170E-02	4.341E-02	TLR2
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.116E-03	1.750E-02	CYP2C9, CYP2C19, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cnidoscolus texanus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities